Labesse G - Search Results

1

Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation.

Mary C, Soflaee MH, Kesavan R, Gelin M, Brown H, Zacharias G, Mathews TP, Lemoff A, Lionne C, Labesse G, Hoxhaj G. Mary C, et al. Among authors: labesse g. Mol Cell. 2022 Sep 1;82(17):3299-3311.e8. doi: 10.1016/j.molcel.2022.06.026. Epub 2022 Jul 21. Mol Cell. 2022. PMID: 35868311 Free PMC article.

2

ROP2 from Toxoplasma gondii: a virulence factor with a protein-kinase fold and no enzymatic activity.

Labesse G, Gelin M, Bessin Y, Lebrun M, Papoin J, Cerdan R, Arold ST, Dubremetz JF. Labesse G, et al. Structure. 2009 Jan 14;17(1):139-46. doi: 10.1016/j.str.2008.11.005. Structure. 2009. PMID: 19141290 Free article.

3

In-plate protein crystallization, in situ ligand soaking and X-ray diffraction.

le Maire A, Gelin M, Pochet S, Hoh F, Pirocchi M, Guichou JF, Ferrer JL, Labesse G. le Maire A, et al. Among authors: labesse g. Acta Crystallogr D Biol Crystallogr. 2011 Sep;67(Pt 9):747-55. doi: 10.1107/S0907444911023249. Epub 2011 Aug 9. Acta Crystallogr D Biol Crystallogr. 2011. PMID: 21904027

4

Screening and in situ synthesis using crystals of a NAD kinase lead to a potent antistaphylococcal compound.

Gelin M, Poncet-Montange G, Assairi L, Morellato L, Huteau V, Dugué L, Dussurget O, Pochet S, Labesse G. Gelin M, et al. Among authors: labesse g. Structure. 2012 Jun 6;20(6):1107-17. doi: 10.1016/j.str.2012.03.024. Epub 2012 May 17. Structure. 2012. PMID: 22608967 Free article.

5

Combining 'dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography.

Gelin M, Delfosse V, Allemand F, Hoh F, Sallaz-Damaz Y, Pirocchi M, Bourguet W, Ferrer JL, Labesse G, Guichou JF. Gelin M, et al. Among authors: labesse g. Acta Crystallogr D Biol Crystallogr. 2015 Aug;71(Pt 8):1777-87. doi: 10.1107/S1399004715010342. Epub 2015 Jul 31. Acta Crystallogr D Biol Crystallogr. 2015. PMID: 26249358

6

Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation.

Labesse G, Alexandre T, Gelin M, Haouz A, Munier-Lehmann H. Labesse G, et al. Acta Crystallogr D Biol Crystallogr. 2015 Sep;71(Pt 9):1890-9. doi: 10.1107/S1399004715013115. Epub 2015 Aug 25. Acta Crystallogr D Biol Crystallogr. 2015. PMID: 26327379

7

8-Thioalkyl-adenosine derivatives inhibit Listeria monocytogenes NAD kinase through a novel binding mode.

Paoletti J, Assairi L, Gelin M, Huteau V, Nahori MA, Dussurget O, Labesse G, Pochet S. Paoletti J, et al. Among authors: labesse g. Eur J Med Chem. 2016 Nov 29;124:1041-1056. doi: 10.1016/j.ejmech.2016.10.033. Epub 2016 Oct 18. Eur J Med Chem. 2016. PMID: 27783975

8

Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation.

Lecointre C, Simon V, Kerneur C, Allemand F, Fournet A, Montarras I, Pons JL, Gelin M, Brignatz C, Urbach S, Labesse G, Roche S. Lecointre C, et al. Among authors: labesse g. Structure. 2018 Apr 3;26(4):545-554.e4. doi: 10.1016/j.str.2018.01.017. Epub 2018 Mar 1. Structure. 2018. PMID: 29503074 Free article.

9

First-in-class allosteric inhibitors of bacterial IMPDHs.

Alexandre T, Lupan A, Helynck O, Vichier-Guerre S, Dugué L, Gelin M, Haouz A, Labesse G, Munier-Lehmann H. Alexandre T, et al. Among authors: labesse g. Eur J Med Chem. 2019 Apr 1;167:124-132. doi: 10.1016/j.ejmech.2019.01.064. Epub 2019 Feb 2. Eur J Med Chem. 2019. PMID: 30769241 Free article.

10

From Substrate to Fragments to Inhibitor Active In Vivo against Staphylococcus aureus.

Gelin M, Paoletti J, Nahori MA, Huteau V, Leseigneur C, Jouvion G, Dugué L, Clément D, Pons JL, Assairi L, Pochet S, Labesse G, Dussurget O. Gelin M, et al. Among authors: labesse g. ACS Infect Dis. 2020 Mar 13;6(3):422-435. doi: 10.1021/acsinfecdis.9b00368. Epub 2020 Feb 14. ACS Infect Dis. 2020. PMID: 32017533

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