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Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice. Evidence that silymarin acts both as an inhibitor of metabolic activation and as a chain-breaking antioxidant.
Lettéron P, Labbe G, Degott C, Berson A, Fromenty B, Delaforge M, Larrey D, Pessayre D. Lettéron P, et al. Among authors: labbe g. Biochem Pharmacol. 1990 Jun 15;39(12):2027-34. doi: 10.1016/0006-2952(90)90625-u. Biochem Pharmacol. 1990. PMID: 2353942
Test systems in drug discovery for hazard identification and risk assessment of human drug-induced liver injury.
Weaver RJ, Betts C, Blomme EAG, Gerets HHJ, Gjervig Jensen K, Hewitt PG, Juhila S, Labbe G, Liguori MJ, Mesens N, Ogese MO, Persson M, Snoeys J, Stevens JL, Walker T, Park BK. Weaver RJ, et al. Among authors: labbe g. Expert Opin Drug Metab Toxicol. 2017 Jul;13(7):767-782. doi: 10.1080/17425255.2017.1341489. Epub 2017 Jun 28. Expert Opin Drug Metab Toxicol. 2017. PMID: 28604124 Review.
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