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The small-molecule compound AC-73 targeting CD147 inhibits leukemic cell proliferation, induces autophagy and increases the chemotherapeutic sensitivity of acute myeloid leukemia cells.
Spinello I, Saulle E, Quaranta MT, Pasquini L, Pelosi E, Castelli G, Ottone T, Voso MT, Testa U, Labbaye C. Spinello I, et al. Among authors: labbaye c. Haematologica. 2019 May;104(5):973-985. doi: 10.3324/haematol.2018.199661. Epub 2018 Nov 22. Haematologica. 2019. PMID: 30467201 Free PMC article.
Targeting Lactate Metabolism by Inhibiting MCT1 or MCT4 Impairs Leukemic Cell Proliferation, Induces Two Different Related Death-Pathways and Increases Chemotherapeutic Sensitivity of Acute Myeloid Leukemia Cells.
Saulle E, Spinello I, Quaranta MT, Pasquini L, Pelosi E, Iorio E, Castelli G, Chirico M, Pisanu ME, Ottone T, Voso MT, Testa U, Labbaye C. Saulle E, et al. Among authors: labbaye c. Front Oncol. 2021 Feb 5;10:621458. doi: 10.3389/fonc.2020.621458. eCollection 2020. Front Oncol. 2021. PMID: 33614502 Free PMC article.
A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis.
Labbaye C, Spinello I, Quaranta MT, Pelosi E, Pasquini L, Petrucci E, Biffoni M, Nuzzolo ER, Billi M, Foà R, Brunetti E, Grignani F, Testa U, Peschle C. Labbaye C, et al. Nat Cell Biol. 2008 Jul;10(7):788-801. doi: 10.1038/ncb1741. Epub 2008 Jun 22. Nat Cell Biol. 2008. PMID: 18568019
34 results