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MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets.
Qiu X, Boufaied N, Hallal T, Feit A, de Polo A, Luoma AM, Alahmadi W, Larocque J, Zadra G, Xie Y, Gu S, Tang Q, Zhang Y, Syamala S, Seo JH, Bell C, O'Connor E, Liu Y, Schaeffer EM, Jeffrey Karnes R, Weinmann S, Davicioni E, Morrissey C, Cejas P, Ellis L, Loda M, Wucherpfennig KW, Pomerantz MM, Spratt DE, Corey E, Freedman ML, Shirley Liu X, Brown M, Long HW, Labbé DP. Qiu X, et al. Among authors: labbe dp. Nat Commun. 2022 May 13;13(1):2559. doi: 10.1038/s41467-022-30257-z. Nat Commun. 2022. PMID: 35562350 Free PMC article.
Role of diet in prostate cancer: the epigenetic link.
Labbé DP, Zadra G, Ebot EM, Mucci LA, Kantoff PW, Loda M, Brown M. Labbé DP, et al. Oncogene. 2015 Sep 3;34(36):4683-91. doi: 10.1038/onc.2014.422. Epub 2014 Dec 22. Oncogene. 2015. PMID: 25531313 Free PMC article. Review.
High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program.
Labbé DP, Zadra G, Yang M, Reyes JM, Lin CY, Cacciatore S, Ebot EM, Creech AL, Giunchi F, Fiorentino M, Elfandy H, Syamala S, Karoly ED, Alshalalfa M, Erho N, Ross A, Schaeffer EM, Gibb EA, Takhar M, Den RB, Lehrer J, Karnes RJ, Freedland SJ, Davicioni E, Spratt DE, Ellis L, Jaffe JD, DʼAmico AV, Kantoff PW, Bradner JE, Mucci LA, Chavarro JE, Loda M, Brown M. Labbé DP, et al. Nat Commun. 2019 Sep 25;10(1):4358. doi: 10.1038/s41467-019-12298-z. Nat Commun. 2019. PMID: 31554818 Free PMC article.
CdGAP promotes prostate cancer metastasis by regulating epithelial-to-mesenchymal transition, cell cycle progression, and apoptosis.
Mehra C, Chung JH, He Y, Lara-Márquez M, Goyette MA, Boufaied N, Barrès V, Ouellet V, Guérard KP, Delliaux C, Saad F, Lapointe J, Côté JF, Labbé DP, Lamarche-Vane N. Mehra C, et al. Among authors: labbe dp. Commun Biol. 2021 Sep 7;4(1):1042. doi: 10.1038/s42003-021-02520-4. Commun Biol. 2021. PMID: 34493786 Free PMC article.
The gut microbiome-prostate cancer crosstalk is modulated by dietary polyunsaturated long-chain fatty acids.
Lachance G, Robitaille K, Laaraj J, Gevariya N, Varin TV, Feldiorean A, Gaignier F, Julien IB, Xu HW, Hallal T, Pelletier JF, Bouslama S, Boufaied N, Derome N, Bergeron A, Ellis L, Piccirillo CA, Raymond F, Fradet Y, Labbé DP, Marette A, Fradet V. Lachance G, et al. Among authors: labbe dp. Nat Commun. 2024 Apr 23;15(1):3431. doi: 10.1038/s41467-024-45332-w. Nat Commun. 2024. PMID: 38654015 Free PMC article.
28 results