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High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program.
Labbé DP, Zadra G, Yang M, Reyes JM, Lin CY, Cacciatore S, Ebot EM, Creech AL, Giunchi F, Fiorentino M, Elfandy H, Syamala S, Karoly ED, Alshalalfa M, Erho N, Ross A, Schaeffer EM, Gibb EA, Takhar M, Den RB, Lehrer J, Karnes RJ, Freedland SJ, Davicioni E, Spratt DE, Ellis L, Jaffe JD, DʼAmico AV, Kantoff PW, Bradner JE, Mucci LA, Chavarro JE, Loda M, Brown M. Labbé DP, et al. Nat Commun. 2019 Sep 25;10(1):4358. doi: 10.1038/s41467-019-12298-z. Nat Commun. 2019. PMID: 31554818 Free PMC article.
Role of diet in prostate cancer: the epigenetic link.
Labbé DP, Zadra G, Ebot EM, Mucci LA, Kantoff PW, Loda M, Brown M. Labbé DP, et al. Oncogene. 2015 Sep 3;34(36):4683-91. doi: 10.1038/onc.2014.422. Epub 2014 Dec 22. Oncogene. 2015. PMID: 25531313 Free PMC article. Review.
ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer.
Deblois G, Smith HW, Tam IS, Gravel SP, Caron M, Savage P, Labbé DP, Bégin LR, Tremblay ML, Park M, Bourque G, St-Pierre J, Muller WJ, Giguère V. Deblois G, et al. Among authors: labbe dp. Nat Commun. 2016 Jul 12;7:12156. doi: 10.1038/ncomms12156. Nat Commun. 2016. PMID: 27402251 Free PMC article.
Gene expression profiling of prostate tissue identifies chromatin regulation as a potential link between obesity and lethal prostate cancer.
Ebot EM, Gerke T, Labbé DP, Sinnott JA, Zadra G, Rider JR, Tyekucheva S, Wilson KM, Kelly RS, Shui IM, Loda M, Kantoff PW, Finn S, Vander Heiden MG, Brown M, Giovannucci EL, Mucci LA. Ebot EM, et al. Among authors: labbe dp. Cancer. 2017 Nov 1;123(21):4130-4138. doi: 10.1002/cncr.30831. Epub 2017 Jul 12. Cancer. 2017. PMID: 28700821 Free PMC article.
TOP2A and EZH2 Provide Early Detection of an Aggressive Prostate Cancer Subgroup.
Labbé DP, Sweeney CJ, Brown M, Galbo P, Rosario S, Wadosky KM, Ku SY, Sjöström M, Alshalalfa M, Erho N, Davicioni E, Karnes RJ, Schaeffer EM, Jenkins RB, Den RB, Ross AE, Bowden M, Huang Y, Gray KP, Feng FY, Spratt DE, Goodrich DW, Eng KH, Ellis L. Labbé DP, et al. Clin Cancer Res. 2017 Nov 15;23(22):7072-7083. doi: 10.1158/1078-0432.CCR-17-0413. Epub 2017 Sep 12. Clin Cancer Res. 2017. PMID: 28899973 Free PMC article.
Transcriptional Regulation in Prostate Cancer.
Labbé DP, Brown M. Labbé DP, et al. Cold Spring Harb Perspect Med. 2018 Nov 1;8(11):a030437. doi: 10.1101/cshperspect.a030437. Cold Spring Harb Perspect Med. 2018. PMID: 29530947 Free PMC article. Review.
EZH2 inhibition activates a dsRNA-STING-interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer.
Morel KL, Sheahan AV, Burkhart DL, Baca SC, Boufaied N, Liu Y, Qiu X, Cañadas I, Roehle K, Heckler M, Calagua C, Ye H, Pantelidou C, Galbo P, Panja S, Mitrofanova A, Wilkinson S, Whitlock NC, Trostel SY, Hamid AA, Kibel AS, Barbie DA, Choudhury AD, Pomerantz MM, Sweeney CJ, Long HW, Einstein DJ, Shapiro GI, Dougan SK, Sowalsky AG, He HH, Freedman ML, Balk SP, Loda M, Labbé DP, Olson BM, Ellis L. Morel KL, et al. Among authors: labbe dp. Nat Cancer. 2021 Apr;2(4):444-456. doi: 10.1038/s43018-021-00185-w. Epub 2021 Mar 22. Nat Cancer. 2021. PMID: 33899001 Free PMC article.
28 results