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Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker.
Taylor MS, Connie W, Fridy PC, Zhang SJ, Senussi Y, Wolters JC, Cheng WC, Heaps J, Miller BD, Mori K, Cohen L, Jiang H, Molloy KR, Norden BL, Chait BT, Goggins M, Bhan I, Franses JW, Yang X, Taplin ME, Wang X, Christiani DC, Johnson BE, Meyerson M, Uppaluri R, Egloff AM, Denault EN, Spring LM, Wang TL, Shih IM, Jung E, Arora KS, Zukerberg LR, Yilmaz OH, Chi G, Matulonis UA, Song Y, Nieman L, Parikh AR, Strickland M, Corcoran RB, Mustelin T, Eng G, Yilmaz ÃH, Skates SJ, Rueda BR, Drapkin R, Klempner SJ, Deshpande V, Ting DT, Rout MP, LaCava J, Walt DR, Burns KH. Taylor MS, et al. Among authors: lacava j. bioRxiv [Preprint]. 2023 Mar 17:2023.01.25.525462. doi: 10.1101/2023.01.25.525462. bioRxiv. 2023. PMID: 36747644 Free PMC article. Updated. Preprint.
Cancer cells co-evolve with retrotransposons to mitigate viral mimicry.
Sun S, Hong J, You E, Tsanov KM, Chacon-Barahona J, Gioacchino AD, Hoyos D, Li H, Jiang H, Ly H, Marhon S, Murali R, Chanda P, Karacay A, Vabret N, De Carvalho DD, LaCava J, Lowe SW, Ting DT, Iacobuzio-Donahue CA, Solovyov A, Greenbaum BD. Sun S, et al. Among authors: lacava j. bioRxiv [Preprint]. 2023 May 20:2023.05.19.541456. doi: 10.1101/2023.05.19.541456. bioRxiv. 2023. PMID: 37292765 Free PMC article. Preprint.
Expression and detection of LINE-1 ORF-encoded proteins.
Dai L, LaCava J, Taylor MS, Boeke JD. Dai L, et al. Among authors: lacava j. Mob Genet Elements. 2014 May 22;4:e29319. doi: 10.4161/mge.29319. eCollection 2014. Mob Genet Elements. 2014. PMID: 25054082 Free PMC article.
Rapid, optimized interactomic screening.
Hakhverdyan Z, Domanski M, Hough LE, Oroskar AA, Oroskar AR, Keegan S, Dilworth DJ, Molloy KR, Sherman V, Aitchison JD, Fenyö D, Chait BT, Jensen TH, Rout MP, LaCava J. Hakhverdyan Z, et al. Among authors: lacava j. Nat Methods. 2015 Jun;12(6):553-60. doi: 10.1038/nmeth.3395. Epub 2015 May 4. Nat Methods. 2015. PMID: 25938370 Free PMC article.
Characterization of L1-Ribonucleoprotein Particles.
Taylor MS, LaCava J, Dai L, Mita P, Burns KH, Rout MP, Boeke JD. Taylor MS, et al. Among authors: lacava j. Methods Mol Biol. 2016;1400:311-38. doi: 10.1007/978-1-4939-3372-3_20. Methods Mol Biol. 2016. PMID: 26895062 Free PMC article.
Dissection of affinity captured LINE-1 macromolecular complexes.
Taylor MS, Altukhov I, Molloy KR, Mita P, Jiang H, Adney EM, Wudzinska A, Badri S, Ischenko D, Eng G, Burns KH, Fenyö D, Chait BT, Alexeev D, Rout MP, Boeke JD, LaCava J. Taylor MS, et al. Among authors: lacava j. Elife. 2018 Jan 8;7:e30094. doi: 10.7554/eLife.30094. Elife. 2018. PMID: 29309035 Free PMC article.
LINE-1 ORF2p expression is nearly imperceptible in human cancers.
Ardeljan D, Wang X, Oghbaie M, Taylor MS, Husband D, Deshpande V, Steranka JP, Gorbounov M, Yang WR, Sie B, Larman HB, Jiang H, Molloy KR, Altukhov I, Li Z, McKerrow W, Fenyö D, Burns KH, LaCava J. Ardeljan D, et al. Among authors: lacava j. Mob DNA. 2019 Dec 31;11:1. doi: 10.1186/s13100-019-0191-2. eCollection 2020. Mob DNA. 2019. PMID: 31892958 Free PMC article.
Affinity proteomic dissection of the human nuclear cap-binding complex interactome.
Dou Y, Kalmykova S, Pashkova M, Oghbaie M, Jiang H, Molloy KR, Chait BT, Rout MP, Fenyö D, Jensen TH, Altukhov I, LaCava J. Dou Y, et al. Among authors: lacava j. Nucleic Acids Res. 2020 Oct 9;48(18):10456-10469. doi: 10.1093/nar/gkaa743. Nucleic Acids Res. 2020. PMID: 32960270 Free PMC article.
87 results