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A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens.
Mattson NM, Chan AKN, Miyashita K, Mukhaleva E, Chang WH, Yang L, Ma N, Wang Y, Pokharel SP, Li M, Liu Q, Xu X, Chen R, Singh P, Zhang L, Elsayed Z, Chen B, Keen D, Pirrotte P, Rosen ST, Chen J, LaBarge MA, Shively JE, Vaidehi N, Rockne RC, Feng M, Chen CW. Mattson NM, et al. Among authors: labarge ma. Nat Struct Mol Biol. 2024 Mar;31(3):465-475. doi: 10.1038/s41594-024-01211-y. Epub 2024 Feb 5. Nat Struct Mol Biol. 2024. PMID: 38316881 Free PMC article.
Comprehensive single cell aging atlas of mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and cancer.
Angarola BL, Sharma S, Katiyar N, Gu Kang H, Nehar-Belaid D, Park S, Gott R, Eryilmaz GN, LaBarge MA, Palucka K, Chuang JH, Korstanje R, Ucar D, Anczukow O. Angarola BL, et al. Among authors: labarge ma. bioRxiv [Preprint]. 2023 Oct 23:2023.10.20.563147. doi: 10.1101/2023.10.20.563147. bioRxiv. 2023. PMID: 37961129 Free PMC article. Preprint.
Configurational entropy is an intrinsic driver of tissue structural heterogeneity.
Srivastava V, Hu JL, Garbe JC, Veytsman B, Shalabi SF, Yllanes D, Thomson M, LaBarge MA, Huber G, Gartner ZJ. Srivastava V, et al. Among authors: labarge ma. bioRxiv [Preprint]. 2023 Jul 2:2023.07.01.546933. doi: 10.1101/2023.07.01.546933. bioRxiv. 2023. PMID: 37425903 Free PMC article. Preprint.
Preneoplastic stromal cells promote BRCA1-mediated breast tumorigenesis.
Nee K, Ma D, Nguyen QH, Pein M, Pervolarakis N, Insua-Rodríguez J, Gong Y, Hernandez G, Alshetaiwi H, Williams J, Rauf M, Dave KR, Boyapati K, Hasnain A, Calderon C, Markaryan A, Edwards R, Lin E, Parajuli R, Zhou P, Nie Q, Shalabi S, LaBarge MA, Kessenbrock K. Nee K, et al. Among authors: labarge ma. Nat Genet. 2023 Apr;55(4):595-606. doi: 10.1038/s41588-023-01298-x. Epub 2023 Mar 13. Nat Genet. 2023. PMID: 36914836 Free PMC article.
70 results