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A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases.
Fujita K, Nakamura Y, Oka T, Ito H, Tamura T, Tagawa K, Sasabe T, Katsuta A, Motoki K, Shiwaku H, Sone M, Yoshida C, Katsuno M, Eishi Y, Murata M, Taylor JP, Wanker EE, Kono K, Tashiro S, Sobue G, La Spada AR, Okazawa H. Fujita K, et al. Among authors: la spada ar. Nat Commun. 2013;4:1816. doi: 10.1038/ncomms2828. Nat Commun. 2013. PMID: 23652004 Free PMC article.
Polyglutamines placed into context.
La Spada AR, Taylor JP. La Spada AR, et al. Neuron. 2003 Jun 5;38(5):681-4. doi: 10.1016/s0896-6273(03)00328-3. Neuron. 2003. PMID: 12797953 Free article. Review.
Something wicked this way comes: huntingtin.
La Spada AR. La Spada AR. Nat Neurosci. 2014 Aug;17(8):1014-5. doi: 10.1038/nn.3770. Nat Neurosci. 2014. PMID: 25065434 No abstract available.
PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically.
Dickey AS, Pineda VV, Tsunemi T, Liu PP, Miranda HC, Gilmore-Hall SK, Lomas N, Sampat KR, Buttgereit A, Torres MJ, Flores AL, Arreola M, Arbez N, Akimov SS, Gaasterland T, Lazarowski ER, Ross CA, Yeo GW, Sopher BL, Magnuson GK, Pinkerton AB, Masliah E, La Spada AR. Dickey AS, et al. Among authors: la spada ar. Nat Med. 2016 Jan;22(1):37-45. doi: 10.1038/nm.4003. Epub 2015 Dec 7. Nat Med. 2016. PMID: 26642438 Free PMC article.
Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscular atrophy.
Badders NM, Korff A, Miranda HC, Vuppala PK, Smith RB, Winborn BJ, Quemin ER, Sopher BL, Dearman J, Messing J, Kim NC, Moore J, Freibaum BD, Kanagaraj AP, Fan B, Tillman H, Chen PC, Wang Y, Freeman BB III, Li Y, Kim HJ, La Spada AR, Taylor JP. Badders NM, et al. Among authors: la spada ar. Nat Med. 2018 May;24(4):427-437. doi: 10.1038/nm.4500. Epub 2018 Mar 5. Nat Med. 2018. PMID: 29505030 Free PMC article.
Expression levels of DNA replication and repair genes predict regional somatic repeat instability in the brain but are not altered by polyglutamine disease protein expression or age.
Mason AG, Tomé S, Simard JP, Libby RT, Bammler TK, Beyer RP, Morton AJ, Pearson CE, La Spada AR. Mason AG, et al. Among authors: la spada ar. Hum Mol Genet. 2014 Mar 15;23(6):1606-18. doi: 10.1093/hmg/ddt551. Epub 2013 Nov 3. Hum Mol Genet. 2014. PMID: 24191263 Free PMC article.
173 results