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Page 1
An Amphotericin B Derivative Equally Potent to Amphotericin B and with Increased Safety.
Antillón A, de Vries AH, Espinosa-Caballero M, Falcón-González JM, Flores Romero D, González-Damián J, Jiménez-Montejo FE, León-Buitimea A, López-Ortiz M, Magaña R, Marrink SJ, Morales-Nava R, Periole X, Reyes-Esparza J, Rodríguez Lozada J, Santiago-Angelino TM, Vargas González MC, Regla I, Carrillo-Tripp M, Fernández-Zertuche M, Rodríguez-Fragoso L, Ortega-Blake I. Antillón A, et al. PLoS One. 2016 Sep 28;11(9):e0162171. doi: 10.1371/journal.pone.0162171. eCollection 2016. PLoS One. 2016. PMID: 27683101 Free PMC article.
The disulfiram metabolites S-methyl-N,N-diethyldithiocarbamoyl sulfoxide and S-methyl-N,N-diethylthiocarbamoyl sulfone irreversibly inactivate betaine aldehyde dehydrogenase from Pseudomonas aeruginosa, both in vitro and in situ, and arrest bacterial growth.
Zaldívar-Machorro VJ, López-Ortiz M, Demare P, Regla I, Muñoz-Clares RA. Zaldívar-Machorro VJ, et al. Biochimie. 2011 Feb;93(2):286-95. doi: 10.1016/j.biochi.2010.09.022. Epub 2010 Oct 7. Biochimie. 2011. PMID: 20933050
Multicomponent synthesis of some new (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-dithiocarbamates and their in vitro anti-proliferative activity against CaSki, MDA-MB-231 and SK-Lu-1 tumour cells as apoptosis inducing agents without necrosis.
Laskar S, Sánchez-Sánchez L, López-Ortiz M, López-Muñoz H, Escobar-Sánchez ML, Sánchez AT, Regla I. Laskar S, et al. J Enzyme Inhib Med Chem. 2017 Dec;32(1):1129-1135. doi: 10.1080/14756366.2017.1363197. J Enzyme Inhib Med Chem. 2017. PMID: 28868930 Free PMC article.
Identification of (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-dithiocarbamate-nitrostyrene hybrid as potent antiproliferative and apoptotic inducing agent against cervical cancer cell lines.
Laskar S, Sánchez-Sánchez L, Flores SM, López-Muñoz H, Escobar-Sánchez ML, López-Ortiz M, Hernández-Rodríguez M, Regla I. Laskar S, et al. Eur J Med Chem. 2018 Feb 25;146:621-635. doi: 10.1016/j.ejmech.2018.01.020. Epub 2018 Jan 10. Eur J Med Chem. 2018. PMID: 29407986
Antiallodynic effect of PhAR-DBH-Me involves cannabinoid and TRPV1 receptors.
Quiñonez-Bastidas GN, Palomino-Hernández O, López-Ortíz M, Rocha-González HI, González-Anduaga GM, Regla I, Navarrete A. Quiñonez-Bastidas GN, et al. Among authors: lopez ortiz m. Pharmacol Res Perspect. 2020 Oct;8(5):e00663. doi: 10.1002/prp2.663. Pharmacol Res Perspect. 2020. PMID: 32965798 Free PMC article.
The critical role of the aldehyde dehydrogenase PauC in spermine, spermidine, and diaminopropane toxicity in Pseudomonas aeruginosa: Its possible use as a drug target.
Cardona-Cardona YV, Regla I, Juárez-Díaz JA, Carrillo-Campos J, López-Ortiz M, Aguilera-Cruz A, Mújica-Jiménez C, Muñoz-Clares RA. Cardona-Cardona YV, et al. Among authors: lopez ortiz m. FEBS J. 2022 May;289(9):2685-2705. doi: 10.1111/febs.16277. Epub 2021 Nov 24. FEBS J. 2022. PMID: 34767295 Free article.
22 results