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The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2.
Chaib S, López-Domínguez JA, Lalinde-Gutiérrez M, Prats N, Marin I, Boix O, García-Garijo A, Meyer K, Muñoz MI, Aguilera M, Mateo L, Stephan-Otto Attolini C, Llanos S, Pérez-Ramos S, Escorihuela M, Al-Shahrour F, Cash TP, Tchkonia T, Kirkland JL, Abad M, Gros A, Arribas J, Serrano M. Chaib S, et al. Among authors: lopez dominguez ja. Nat Cancer. 2024 Mar;5(3):448-462. doi: 10.1038/s43018-023-00712-x. Epub 2024 Jan 24. Nat Cancer. 2024. PMID: 38267628 Free PMC article.
Cellular Senescence Is Immunogenic and Promotes Antitumor Immunity.
Marin I, Boix O, Garcia-Garijo A, Sirois I, Caballe A, Zarzuela E, Ruano I, Attolini CS, Prats N, López-Domínguez JA, Kovatcheva M, Garralda E, Muñoz J, Caron E, Abad M, Gros A, Pietrocola F, Serrano M. Marin I, et al. Among authors: lopez dominguez ja. Cancer Discov. 2023 Feb 6;13(2):410-431. doi: 10.1158/2159-8290.CD-22-0523. Cancer Discov. 2023. PMID: 36302218 Free PMC article.
Senescence-associated morphological profiles (SAMPs): an image-based phenotypic profiling method for evaluating the inter and intra model heterogeneity of senescence.
Wallis R, Milligan D, Hughes B, Mizen H, López-Domínguez JA, Eduputa U, Tyler EJ, Serrano M, Bishop CL. Wallis R, et al. Among authors: lopez dominguez ja. Aging (Albany NY). 2022 May 16;14(10):4220-4246. doi: 10.18632/aging.204072. Epub 2022 May 16. Aging (Albany NY). 2022. PMID: 35580013 Free PMC article.
A Two-Photon Probe Based on Naphthalimide-Styrene Fluorophore for the In Vivo Tracking of Cellular Senescence.
Lozano-Torres B, Blandez JF, Galiana I, Lopez-Dominguez JA, Rovira M, Paez-Ribes M, González-Gualda E, Muñoz-Espín D, Serrano M, Sancenón F, Martínez-Máñez R. Lozano-Torres B, et al. Among authors: lopez dominguez ja. Anal Chem. 2021 Feb 9;93(5):3052-3060. doi: 10.1021/acs.analchem.0c05447. Epub 2021 Jan 27. Anal Chem. 2021. PMID: 33502178 Free PMC article.
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages.
Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E. Covarrubias AJ, et al. Nat Metab. 2020 Nov;2(11):1265-1283. doi: 10.1038/s42255-020-00305-3. Epub 2020 Nov 16. Nat Metab. 2020. PMID: 33199924 Free PMC article.
Author Correction: Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages.
Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E. Covarrubias AJ, et al. Among authors: lopez dominguez ja. Nat Metab. 2021 Jan;3(1):120-121. doi: 10.1038/s42255-020-00328-w. Nat Metab. 2021. PMID: 33303985 No abstract available.
SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells.
Wiley CD, Liu S, Limbad C, Zawadzka AM, Beck J, Demaria M, Artwood R, Alimirah F, Lopez-Dominguez JA, Kuehnemann C, Danielson SR, Basisty N, Kasler HG, Oron TR, Desprez PY, Mooney SD, Gibson BW, Schilling B, Campisi J, Kapahi P. Wiley CD, et al. Cell Rep. 2019 Sep 24;28(13):3329-3337.e5. doi: 10.1016/j.celrep.2019.08.049. Cell Rep. 2019. PMID: 31553904 Free PMC article.
Cdkn1a transcript variant 2 is a marker of aging and cellular senescence.
López-Domínguez JA, Rodríguez-López S, Ahumada-Castro U, Desprez PY, Konovalenko M, Laberge RM, Cárdenas C, Villalba JM, Campisi J. López-Domínguez JA, et al. Aging (Albany NY). 2021 May 25;13(10):13380-13392. doi: 10.18632/aging.203110. Epub 2021 May 25. Aging (Albany NY). 2021. PMID: 34035185 Free PMC article.
Human senescent fibroblasts trigger progressive lung fibrosis in mice.
Hernandez-Gonzalez F, Prats N, Ramponi V, López-Domínguez JA, Meyer K, Aguilera M, Muñoz Martín MI, Martínez D, Agusti A, Faner R, Sellarés J, Pietrocola F, Serrano M. Hernandez-Gonzalez F, et al. Among authors: lopez dominguez ja. Aging (Albany NY). 2023 Jul 1;15(14):6641-6657. doi: 10.18632/aging.204825. Epub 2023 Jul 1. Aging (Albany NY). 2023. PMID: 37393107 Free PMC article.
Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis.
Wiley CD, Sharma R, Davis SS, Lopez-Dominguez JA, Mitchell KP, Wiley S, Alimirah F, Kim DE, Payne T, Rosko A, Aimontche E, Deshpande SM, Neri F, Kuehnemann C, Demaria M, Ramanathan A, Campisi J. Wiley CD, et al. Among authors: lopez dominguez ja. Cell Metab. 2021 Jun 1;33(6):1124-1136.e5. doi: 10.1016/j.cmet.2021.03.008. Epub 2021 Apr 2. Cell Metab. 2021. PMID: 33811820 Free PMC article.
27 results