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The parkinsonian LRRK2 R1441G mutation shows macroautophagy-mitophagy dysregulation concomitant with endoplasmic reticulum stress.
Yakhine-Diop SMS, Rodríguez-Arribas M, Canales-Cortés S, Martínez-Chacón G, Uribe-Carretero E, Blanco-Benítez M, Duque-González G, Paredes-Barquero M, Alegre-Cortés E, Climent V, Aiastui A, López de Munain A, Bravo-San Pedro JM, Niso-Santano M, Fuentes JM, González-Polo RA. Yakhine-Diop SMS, et al. Among authors: lopez de munain a. Cell Biol Toxicol. 2022 Oct;38(5):889-911. doi: 10.1007/s10565-021-09617-w. Epub 2021 May 31. Cell Biol Toxicol. 2022. PMID: 34060004
Neuropathology of Parkinson's disease with the R1441G mutation in LRRK2.
Martí-Massó JF, Ruiz-Martínez J, Bolaño MJ, Ruiz I, Gorostidi A, Moreno F, Ferrer I, López de Munain A. Martí-Massó JF, et al. Among authors: lopez de munain a. Mov Disord. 2009 Oct 15;24(13):1998-2001. doi: 10.1002/mds.22677. Mov Disord. 2009. PMID: 19735093
The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway.
Bravo-San Pedro JM, Niso-Santano M, Gómez-Sánchez R, Pizarro-Estrella E, Aiastui-Pujana A, Gorostidi A, Climent V, López de Maturana R, Sanchez-Pernaute R, López de Munain A, Fuentes JM, González-Polo RA. Bravo-San Pedro JM, et al. Among authors: lopez de munain a, lopez de maturana r. Cell Mol Life Sci. 2013 Jan;70(1):121-36. doi: 10.1007/s00018-012-1061-y. Epub 2012 Jul 8. Cell Mol Life Sci. 2013. PMID: 22773119
The MAPK1/3 pathway is essential for the deregulation of autophagy observed in G2019S LRRK2 mutant fibroblasts.
Bravo-San Pedro JM, Gómez-Sánchez R, Niso-Santano M, Pizarro-Estrella E, Aiastui-Pujana A, Gorostidi A, Climent V, López de Maturana R, Sanchez-Pernaute R, López de Munain A, Fuentes JM, González-Polo RA. Bravo-San Pedro JM, et al. Among authors: lopez de munain a, lopez de maturana r. Autophagy. 2012 Oct;8(10):1537-9. doi: 10.4161/auto.21270. Epub 2012 Aug 23. Autophagy. 2012. PMID: 22914360 Free PMC article.
Αlpha-synuclein levels in blood plasma from LRRK2 mutation carriers.
Gorostidi A, Bergareche A, Ruiz-Martínez J, Martí-Massó JF, Cruz M, Varghese S, Qureshi MM, Alzahmi F, Al-Hayani A, López de Munáin A, El-Agnaf OM. Gorostidi A, et al. Among authors: lopez de munain a. PLoS One. 2012;7(12):e52312. doi: 10.1371/journal.pone.0052312. Epub 2012 Dec 27. PLoS One. 2012. PMID: 23300640 Free PMC article.
Murine muscle engineered from dermal precursors: an in vitro model for skeletal muscle generation, degeneration, and fatty infiltration.
García-Parra P, Naldaiz-Gastesi N, Maroto M, Padín JF, Goicoechea M, Aiastui A, Fernández-Morales JC, García-Belda P, Lacalle J, Álava JI, García-Verdugo JM, García AG, Izeta A, López de Munain A. García-Parra P, et al. Among authors: lopez de munain a. Tissue Eng Part C Methods. 2014 Jan;20(1):28-41. doi: 10.1089/ten.TEC.2013.0146. Epub 2013 Jun 22. Tissue Eng Part C Methods. 2014. PMID: 23631552 Free PMC article.
356 results