Lévay G - Search Results

1

HTS-based discovery and optimization of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor.

Ledneczki I, Horváth A, Tapolcsányi P, Éles J, Molnár KD, Vágó I, Visegrády A, Kiss L, Szigetvári Á, Kóti J, Krámos B, Mahó S, Holm P, Kolok S, Fodor L, Thán M, Kostyalik D, Balázs O, Vastag M, Greiner I, Lévay G, Lendvai B, Némethy Z. Ledneczki I, et al. Among authors: levay g. Eur J Med Chem. 2021 Oct 15;222:113560. doi: 10.1016/j.ejmech.2021.113560. Epub 2021 May 29. Eur J Med Chem. 2021. PMID: 34111828

2

Discovery of novel steroidal histamine H₃ receptor antagonists/inverse agonists.

Ledneczki I, Tapolcsányi P, Gábor E, Éles J, Greiner I, Schmidt É, Némethy Z, Kedves RS, Balázs O, Román V, Lévay G, Mahó S. Ledneczki I, et al. Among authors: levay g. Bioorg Med Chem Lett. 2017 Oct 1;27(19):4525-4530. doi: 10.1016/j.bmcl.2017.08.060. Epub 2017 Sep 1. Bioorg Med Chem Lett. 2017. PMID: 28888822

3

Discovery of novel steroidal histamine H₃ receptor antagonists/inverse agonists. Part 2. Versatile steroidal carboxamide derivatives.

Ledneczki I, Némethy Z, Tapolcsányi P, Éles J, Greiner I, Gábor E, Varga B, Balázs O, Román V, Lévay G, Mahó S. Ledneczki I, et al. Among authors: levay g. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126643. doi: 10.1016/j.bmcl.2019.126643. Epub 2019 Aug 28. Bioorg Med Chem Lett. 2019. PMID: 31492518

4

Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach.

Ledneczki I, Tapolcsányi P, Gábor E, Visegrády A, Vass M, Éles J, Holm P, Horváth A, Pocsai A, Mahó S, Greiner I, Krámos B, Béni Z, Kóti J, Káncz AE, Thán M, Kolok S, Laszy J, Balázs O, Bugovits G, Nagy J, Vastag M, Szájli Á, Bozó É, Lévay G, Lendvai B, Némethy Z. Ledneczki I, et al. Among authors: levay g. Eur J Med Chem. 2021 Mar 15;214:113189. doi: 10.1016/j.ejmech.2021.113189. Epub 2021 Jan 14. Eur J Med Chem. 2021. PMID: 33540354

5

Fragment Based Optimization of Metabotropic Glutamate Receptor 2 (mGluR2) Positive Allosteric Modulators in the Absence of Structural Information.

Szabó G, Túrós GI, Kolok S, Vastag M, Sánta Z, Dékány M, Lévay GI, Greiner I, Natsumi M, Tatsuya W, Keserű GM. Szabó G, et al. Among authors: levay gi. J Med Chem. 2019 Jan 10;62(1):234-246. doi: 10.1021/acs.jmedchem.8b00161. Epub 2018 Mar 14. J Med Chem. 2019. PMID: 29505715

6

Discovery of dihydropyrazino-benzimidazole derivatives as metabotropic glutamate receptor-2 (mGluR2) positive allosteric modulators (PAMs).

Szabó G, Kolok S, Orgován Z, Vastag M, Béni Z, Kóti J, Sághy K, Lévay GI, Greiner I, Keserű GM. Szabó G, et al. Among authors: levay gi. Eur J Med Chem. 2020 Jan 15;186:111881. doi: 10.1016/j.ejmech.2019.111881. Epub 2019 Nov 15. Eur J Med Chem. 2020. PMID: 31780081

7

Fragment-Based Optimization of Dihydropyrazino-Benzimidazolones as Metabotropic Glutamate Receptor-2 Positive Allosteric Modulators against Migraine.

Szabó G, Erdélyi P, Kolok S, Vastag M, Halász AS, Kis-Varga I, Lévay GI, Béni Z, Kóti J, Greiner I, Keserű GM. Szabó G, et al. Among authors: levay gi. J Med Chem. 2021 Jun 24;64(12):8607-8620. doi: 10.1021/acs.jmedchem.1c00563. Epub 2021 Jun 3. J Med Chem. 2021. PMID: 34080424

8

Convergent cross-species pro-cognitive effects of RGH-235, a new potent and selective histamine H₃ receptor antagonist/inverse agonist.

Némethy Z, Kiss B, Lethbridge N, Chazot P, Hajnik T, Tóth A, Détári L, Schmidt É, Czurkó A, Kostyalik D, Oláh V, Hernádi I, Balázs O, Vizi ES, Ledneczki I, Mahó S, Román V, Lendvai B, Lévay G. Némethy Z, et al. Among authors: levay g. Eur J Pharmacol. 2022 Feb 5;916:174621. doi: 10.1016/j.ejphar.2021.174621. Epub 2021 Dec 26. Eur J Pharmacol. 2022. PMID: 34965389

9

Neuronal Dopamine D3 Receptors: Translational Implications for Preclinical Research and CNS Disorders.

Kiss B, Laszlovszky I, Krámos B, Visegrády A, Bobok A, Lévay G, Lendvai B, Román V. Kiss B, et al. Among authors: levay g. Biomolecules. 2021 Jan 14;11(1):104. doi: 10.3390/biom11010104. Biomolecules. 2021. PMID: 33466844 Free PMC article. Review.

10

Kostyalik D, Kelemen K, Lendvai B, Hernádi I, Román V, Lévay G. Kostyalik D, et al. Among authors: levay g. Sci Rep. 2022 May 17;12(1):8168. doi: 10.1038/s41598-022-12146-z. Sci Rep. 2022. PMID: 35581280 Free PMC article.

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