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Evolving DNA methylation and gene expression markers of B-cell chronic lymphocytic leukemia are present in pre-diagnostic blood samples more than 10 years prior to diagnosis.
Georgiadis P, Liampa I, Hebels DG, Krauskopf J, Chatziioannou A, Valavanis I, de Kok TMCM, Kleinjans JCS, Bergdahl IA, Melin B, Spaeth F, Palli D, Vermeulen RCH, Vlaanderen J, Chadeau-Hyam M, Vineis P, Kyrtopoulos SA; EnviroGenomarkers consortium. Georgiadis P, et al. Among authors: kyrtopoulos sa. BMC Genomics. 2017 Sep 13;18(1):728. doi: 10.1186/s12864-017-4117-4. BMC Genomics. 2017. PMID: 28903739 Free PMC article.
Omics for prediction of environmental health effects: Blood leukocyte-based cross-omic profiling reliably predicts diseases associated with tobacco smoking.
Georgiadis P, Hebels DG, Valavanis I, Liampa I, Bergdahl IA, Johansson A, Palli D, Chadeau-Hyam M, Chatziioannou A, Jennen DG, Krauskopf J, Jetten MJ, Kleinjans JC, Vineis P, Kyrtopoulos SA; EnviroGenomarkers consortium. Georgiadis P, et al. Among authors: kyrtopoulos sa. Sci Rep. 2016 Feb 3;6:20544. doi: 10.1038/srep20544. Sci Rep. 2016. PMID: 26837704 Free PMC article.
Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases.
Chatziioannou A, Georgiadis P, Hebels DG, Liampa I, Valavanis I, Bergdahl IA, Johansson A, Palli D, Chadeau-Hyam M, Siskos AP, Keun H, Botsivali M, de Kok TM, Pérez AE, Kleinjans JC, Vineis P, Kyrtopoulos SA; EnviroGenomarkers project consortium. Chatziioannou A, et al. Among authors: kyrtopoulos sa. Sci Rep. 2017 Feb 22;7:42870. doi: 10.1038/srep42870. Sci Rep. 2017. PMID: 28225026 Free PMC article.
Exploring the nature of prediagnostic blood transcriptome markers of chronic lymphocytic leukemia by assessing their overlap with the transcriptome at the clinical stage.
Vlaanderen J, Leenders M, Chadeau-Hyam M, Portengen L, Kyrtopoulos SA, Bergdahl IA, Johansson AS, Hebels DD, de Kok TM, Vineis P, Vermeulen RC. Vlaanderen J, et al. Among authors: kyrtopoulos sa. BMC Genomics. 2017 Mar 20;18(1):239. doi: 10.1186/s12864-017-3627-4. BMC Genomics. 2017. PMID: 28320322 Free PMC article.
DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia.
Georgiadis P, Gavriil M, Rantakokko P, Ladoukakis E, Botsivali M, Kelly RS, Bergdahl IA, Kiviranta H, Vermeulen RCH, Spaeth F, Hebbels DGAJ, Kleinjans JCS, de Kok TMCM, Palli D, Vineis P, Kyrtopoulos SA; EnviroGenomarkers consortium. Georgiadis P, et al. Among authors: kyrtopoulos sa. Environ Int. 2019 May;126:24-36. doi: 10.1016/j.envint.2019.01.068. Epub 2019 Feb 15. Environ Int. 2019. PMID: 30776747 Free PMC article.
Prediagnostic transcriptomic markers of Chronic lymphocytic leukemia reveal perturbations 10 years before diagnosis.
Chadeau-Hyam M, Vermeulen RC, Hebels DG, Castagné R, Campanella G, Portengen L, Kelly RS, Bergdahl IA, Melin B, Hallmans G, Palli D, Krogh V, Tumino R, Sacerdote C, Panico S, de Kok TM, Smith MT, Kleinjans JC, Vineis P, Kyrtopoulos SA; EnviroGenoMarkers project consortium. Chadeau-Hyam M, et al. Among authors: kyrtopoulos sa. Ann Oncol. 2014 May;25(5):1065-72. doi: 10.1093/annonc/mdu056. Epub 2014 Feb 20. Ann Oncol. 2014. PMID: 24558024 Free PMC article.
Associations Between Genome-wide Gene Expression and Ambient Nitrogen Oxides.
Mostafavi N, Vlaanderen J, Portengen L, Chadeau-Hyam M, Modig L, Palli D, Bergdahl IA, Brunekreef B, Vineis P, Hebels DG, Kleinjans JC, Krogh V, Hoek G, Georgiadis P, Kyrtopoulos S, Vermeulen R. Mostafavi N, et al. Epidemiology. 2017 May;28(3):320-328. doi: 10.1097/EDE.0000000000000628. Epidemiology. 2017. PMID: 28151741 Free article.
Dynamics of smoking-induced genome-wide methylation changes with time since smoking cessation.
Guida F, Sandanger TM, Castagné R, Campanella G, Polidoro S, Palli D, Krogh V, Tumino R, Sacerdote C, Panico S, Severi G, Kyrtopoulos SA, Georgiadis P, Vermeulen RC, Lund E, Vineis P, Chadeau-Hyam M. Guida F, et al. Among authors: kyrtopoulos sa. Hum Mol Genet. 2015 Apr 15;24(8):2349-59. doi: 10.1093/hmg/ddu751. Epub 2015 Jan 2. Hum Mol Genet. 2015. PMID: 25556184 Free PMC article.
Biological marks of early-life socioeconomic experience is detected in the adult inflammatory transcriptome.
Castagné R, Kelly-Irving M, Campanella G, Guida F, Krogh V, Palli D, Panico S, Sacerdote C, Tumino R, Kleinjans J, de Kok T, Kyrtopoulos SA, Lang T, Stringhini S, Vermeulen R, Vineis P, Delpierre C, Chadeau-Hyam M. Castagné R, et al. Among authors: kyrtopoulos sa. Sci Rep. 2016 Dec 9;6:38705. doi: 10.1038/srep38705. Sci Rep. 2016. PMID: 27934951 Free PMC article. Clinical Trial.
168 results