Kyle DE - Search Results

1

Spirocyclic chromanes exhibit antiplasmodial activities and inhibit all intraerythrocytic life cycle stages.

Roberts BF, Iyamu ID, Lee S, Lee E, Ayong L, Kyle DE, Yuan Y, Manetsch R, Chakrabarti D. Roberts BF, et al. Among authors: kyle de. Int J Parasitol Drugs Drug Resist. 2016 Feb 12;6(1):85-92. doi: 10.1016/j.ijpddr.2016.02.004. eCollection 2016 Apr. Int J Parasitol Drugs Drug Resist. 2016. PMID: 27054067 Free PMC article.

2

Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity.

Cross RM, Monastyrskyi A, Mutka TS, Burrows JN, Kyle DE, Manetsch R. Cross RM, et al. Among authors: kyle de. J Med Chem. 2010 Oct 14;53(19):7076-94. doi: 10.1021/jm1007903. J Med Chem. 2010. PMID: 20828199

3

Optimization of 1,2,3,4-tetrahydroacridin-9(10H)-ones as antimalarials utilizing structure-activity and structure-property relationships.

Cross RM, Maignan JR, Mutka TS, Luong L, Sargent J, Kyle DE, Manetsch R. Cross RM, et al. Among authors: kyle de. J Med Chem. 2011 Jul 14;54(13):4399-426. doi: 10.1021/jm200015a. Epub 2011 Jun 16. J Med Chem. 2011. PMID: 21630666

4

Synthesis, antimalarial activity, and structure-activity relationship of 7-(2-phenoxyethoxy)-4(1H)-quinolones.

Cross RM, Namelikonda NK, Mutka TS, Luong L, Kyle DE, Manetsch R. Cross RM, et al. Among authors: kyle de. J Med Chem. 2011 Dec 22;54(24):8321-7. doi: 10.1021/jm200718m. Epub 2011 Nov 23. J Med Chem. 2011. PMID: 22111907 Free PMC article.

5

Novel 4-aminoquinoline analogs highly active against the blood and sexual stages of Plasmodium in vivo and in vitro.

Sáenz FE, Mutka T, Udenze K, Oduola AM, Kyle DE. Sáenz FE, et al. Among authors: kyle de. Antimicrob Agents Chemother. 2012 Sep;56(9):4685-92. doi: 10.1128/AAC.01061-12. Epub 2012 Jun 18. Antimicrob Agents Chemother. 2012. PMID: 22710117 Free PMC article.

6

4(1H)-Quinolones with liver stage activity against Plasmodium berghei.

Lacrue AN, Sáenz FE, Cross RM, Udenze KO, Monastyrskyi A, Stein S, Mutka TS, Manetsch R, Kyle DE. Lacrue AN, et al. Among authors: kyle de. Antimicrob Agents Chemother. 2013 Jan;57(1):417-24. doi: 10.1128/AAC.00793-12. Epub 2012 Nov 5. Antimicrob Agents Chemother. 2013. PMID: 23129047 Free PMC article.

7

Quinolone-3-diarylethers: a new class of antimalarial drug.

Nilsen A, LaCrue AN, White KL, Forquer IP, Cross RM, Marfurt J, Mather MW, Delves MJ, Shackleford DM, Saenz FE, Morrisey JM, Steuten J, Mutka T, Li Y, Wirjanata G, Ryan E, Duffy S, Kelly JX, Sebayang BF, Zeeman AM, Noviyanti R, Sinden RE, Kocken CHM, Price RN, Avery VM, Angulo-Barturen I, Jiménez-Díaz MB, Ferrer S, Herreros E, Sanz LM, Gamo FJ, Bathurst I, Burrows JN, Siegl P, Guy RK, Winter RW, Vaidya AB, Charman SA, Kyle DE, Manetsch R, Riscoe MK. Nilsen A, et al. Among authors: kyle de. Sci Transl Med. 2013 Mar 20;5(177):177ra37. doi: 10.1126/scitranslmed.3005029. Sci Transl Med. 2013. PMID: 23515079 Free PMC article.

8

4-(1H)-Quinolones and 1,2,3,4-Tetrahydroacridin-9(10H)-ones prevent the transmission of Plasmodium falciparum to Anopheles freeborni.

Sáenz FE, Lacrue AN, Cross RM, Maignan JR, Udenze KO, Manetsch R, Kyle DE. Sáenz FE, et al. Among authors: kyle de. Antimicrob Agents Chemother. 2013 Dec;57(12):6187-95. doi: 10.1128/AAC.00492-13. Epub 2013 Sep 30. Antimicrob Agents Chemother. 2013. PMID: 24080648 Free PMC article.

9

Antileishmanial activity of a series of N²,N⁴-disubstituted quinazoline-2,4-diamines.

Van Horn KS, Zhu X, Pandharkar T, Yang S, Vesely B, Vanaerschot M, Dujardin JC, Rijal S, Kyle DE, Wang MZ, Werbovetz KA, Manetsch R. Van Horn KS, et al. Among authors: kyle de. J Med Chem. 2014 Jun 26;57(12):5141-56. doi: 10.1021/jm5000408. Epub 2014 Jun 17. J Med Chem. 2014. PMID: 24874647 Free PMC article.

10

4(1H)-pyridone and 4(1H)-quinolone derivatives as antimalarials with erythrocytic, exoerythrocytic, and transmission blocking activities.

Monastyrskyi A, Kyle DE, Manetsch R. Monastyrskyi A, et al. Among authors: kyle de. Curr Top Med Chem. 2014;14(14):1693-705. doi: 10.2174/1568026614666140808124638. Curr Top Med Chem. 2014. PMID: 25116582 Free PMC article.

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