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Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease.
Sci Transl Med. 2021 May 12;13(593):eabb2639. doi: 10.1126/scitranslmed.abb2639.
Sci Transl Med. 2021.
PMID: 33980574
Clinical Trial.
Molecular Understanding of USP7 Substrate Recognition and C-Terminal Activation.
Rougé L, Bainbridge TW, Kwok M, Tong R, Di Lello P, Wertz IE, Maurer T, Ernst JA, Murray J.
Rougé L, et al.
Structure. 2016 Aug 2;24(8):1335-1345. doi: 10.1016/j.str.2016.05.020. Epub 2016 Jul 21.
Structure. 2016.
PMID: 27452404
Free article.
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USP7 small-molecule inhibitors interfere with ubiquitin binding.
Kategaya L, Di Lello P, Rougé L, Pastor R, Clark KR, Drummond J, Kleinheinz T, Lin E, Upton JP, Prakash S, Heideker J, McCleland M, Ritorto MS, Alessi DR, Trost M, Bainbridge TW, Kwok MCM, Ma TP, Stiffler Z, Brasher B, Tang Y, Jaishankar P, Hearn BR, Renslo AR, Arkin MR, Cohen F, Yu K, Peale F, Gnad F, Chang MT, Klijn C, Blackwood E, Martin SE, Forrest WF, Ernst JA, Ndubaku C, Wang X, Beresini MH, Tsui V, Schwerdtfeger C, Blake RA, Murray J, Maurer T, Wertz IE.
Kategaya L, et al. Among authors: kwok mcm.
Nature. 2017 Oct 26;550(7677):534-538. doi: 10.1038/nature24006. Epub 2017 Oct 18.
Nature. 2017.
PMID: 29045385
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Localization, purification, and functional reconstitution of the P4-ATPase Atp8a2, a phosphatidylserine flippase in photoreceptor disc membranes.
Coleman JA, Kwok MC, Molday RS.
Coleman JA, et al.
J Biol Chem. 2009 Nov 20;284(47):32670-9. doi: 10.1074/jbc.M109.047415. Epub 2009 Sep 24.
J Biol Chem. 2009.
PMID: 19778899
Free PMC article.
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Proteomics of photoreceptor outer segments identifies a subset of SNARE and Rab proteins implicated in membrane vesicle trafficking and fusion.
Kwok MC, Holopainen JM, Molday LL, Foster LJ, Molday RS.
Kwok MC, et al.
Mol Cell Proteomics. 2008 Jun;7(6):1053-66. doi: 10.1074/mcp.M700571-MCP200. Epub 2008 Jan 31.
Mol Cell Proteomics. 2008.
PMID: 18245078
Free PMC article.
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