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trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo.
Aron ZD, Mehrani A, Hoffer ED, Connolly KL, Srinivas P, Torhan MC, Alumasa JN, Cabrera M, Hosangadi D, Barbor JS, Cardinale SC, Kwasny SM, Morin LR, Butler MM, Opperman TJ, Bowlin TL, Jerse A, Stagg SM, Dunham CM, Keiler KC. Aron ZD, et al. Among authors: kwasny sm. Nat Commun. 2021 Mar 19;12(1):1799. doi: 10.1038/s41467-021-22012-7. Nat Commun. 2021. PMID: 33741965 Free PMC article.
Detour of prenostodione synthesis towards pyrazolones for antibacterial activity.
Rasapalli S, Fan Y, Yu M, Rees C, Harris JT, Golen JA, Jasinski JP, Rheingold AL, Kwasny SM, Opperman TJ. Rasapalli S, et al. Among authors: kwasny sm. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3235-8. doi: 10.1016/j.bmcl.2013.03.123. Epub 2013 Apr 6. Bioorg Med Chem Lett. 2013. PMID: 23611730
Structure-activity exploration of a small-molecule Lipid II inhibitor.
Fletcher S, Yu W, Huang J, Kwasny SM, Chauhan J, Opperman TJ, MacKerell AD Jr, de Leeuw E. Fletcher S, et al. Among authors: kwasny sm. Drug Des Devel Ther. 2015 Apr 24;9:2383-94. doi: 10.2147/DDDT.S79504. eCollection 2015. Drug Des Devel Ther. 2015. PMID: 25987836 Free PMC article.
17 results