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Dicoumarol, an NQO1 inhibitor, blocks cccDNA transcription by promoting degradation of HBx.
Cheng ST, Hu JL, Ren JH, Yu HB, Zhong S, Wai Wong VK, Kwan Law BY, Chen WX, Xu HM, Zhang ZZ, Cai XF, Hu Y, Zhang WL, Long QX, Ren F, Zhou HZ, Huang AL, Chen J. Cheng ST, et al. Among authors: kwan law by. J Hepatol. 2021 Mar;74(3):522-534. doi: 10.1016/j.jhep.2020.09.019. Epub 2020 Sep 25. J Hepatol. 2021. PMID: 32987030 Free article.
NAD(P)H: Quinone oxidoreductase 1 overexpression in hepatocellular carcinoma potentiates apoptosis evasion through regulating stabilization of X-linked inhibitor of apoptosis protein.
Li WY, Zhou HZ, Chen Y, Cai XF, Tang H, Ren JH, Wai Wong VK, Kwan Law BY, Chen Y, Cheng ST, Yu HB, Cai HY, Chen WX, Tang N, Zhang WL, Tao NN, Yang QX, Ren F, He L, Jiang H, Huang AL, Chen J. Li WY, et al. Among authors: kwan law by. Cancer Lett. 2019 Jun 1;451:156-167. doi: 10.1016/j.canlet.2019.02.053. Epub 2019 Mar 10. Cancer Lett. 2019. PMID: 30867140
HM30181A, a potent P-glycoprotein inhibitor, potentiates the absorption and in vivo antitumor efficacy of paclitaxel in an orthotopic brain tumor model.
Zeng W, Kwan Law BY, Wai Wong VK, Bik Chan DS, Fai Mok SW, Ying Gao JJ, Yan Ho RK, Liang X, Li JH, Lee MT, Yoon WL, Smolinski MP, Nam Lau JY, Kei Lam CW, Fok M. Zeng W, et al. Among authors: kwan law by. Cancer Biol Med. 2020 Nov 15;17(4):986-1001. doi: 10.20892/j.issn.2095-3941.2020.0128. Epub 2020 Dec 15. Cancer Biol Med. 2020. PMID: 33299648 Free PMC article.