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Multimodal Functionalities of HIV-1 Integrase.
Engelman AN, Kvaratskhelia M. Engelman AN, et al. Among authors: kvaratskhelia m. Viruses. 2022 Apr 28;14(5):926. doi: 10.3390/v14050926. Viruses. 2022. PMID: 35632668 Free PMC article. Review.
HIV-1 Integrase-DNA Recognition Mechanisms.
Kessl JJ, McKee CJ, Eidahl JO, Shkriabai N, Katz A, Kvaratskhelia M. Kessl JJ, et al. Among authors: kvaratskhelia m. Viruses. 2009 Dec;1(3):713-36. doi: 10.3390/v1030713. Epub 2009 Nov 5. Viruses. 2009. PMID: 21994566 Free PMC article.
Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors.
Kessl JJ, Jena N, Koh Y, Taskent-Sezgin H, Slaughter A, Feng L, de Silva S, Wu L, Le Grice SF, Engelman A, Fuchs JR, Kvaratskhelia M. Kessl JJ, et al. Among authors: kvaratskhelia m. J Biol Chem. 2012 May 11;287(20):16801-11. doi: 10.1074/jbc.M112.354373. Epub 2012 Mar 21. J Biol Chem. 2012. PMID: 22437836 Free PMC article.
HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.
Wang H, Jurado KA, Wu X, Shun MC, Li X, Ferris AL, Smith SJ, Patel PA, Fuchs JR, Cherepanov P, Kvaratskhelia M, Hughes SH, Engelman A. Wang H, et al. Among authors: kvaratskhelia m. Nucleic Acids Res. 2012 Dec;40(22):11518-30. doi: 10.1093/nar/gks913. Epub 2012 Oct 5. Nucleic Acids Res. 2012. PMID: 23042676 Free PMC article.
The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.
Feng L, Sharma A, Slaughter A, Jena N, Koh Y, Shkriabai N, Larue RC, Patel PA, Mitsuya H, Kessl JJ, Engelman A, Fuchs JR, Kvaratskhelia M. Feng L, et al. Among authors: kvaratskhelia m. J Biol Chem. 2013 May 31;288(22):15813-20. doi: 10.1074/jbc.M112.443390. Epub 2013 Apr 24. J Biol Chem. 2013. PMID: 23615903 Free PMC article.
Allosteric inhibition of HIV-1 integrase activity.
Engelman A, Kessl JJ, Kvaratskhelia M. Engelman A, et al. Among authors: kvaratskhelia m. Curr Opin Chem Biol. 2013 Jun;17(3):339-45. doi: 10.1016/j.cbpa.2013.04.010. Epub 2013 May 3. Curr Opin Chem Biol. 2013. PMID: 23647983 Free PMC article. Review.
A new class of multimerization selective inhibitors of HIV-1 integrase.
Sharma A, Slaughter A, Jena N, Feng L, Kessl JJ, Fadel HJ, Malani N, Male F, Wu L, Poeschla E, Bushman FD, Fuchs JR, Kvaratskhelia M. Sharma A, et al. Among authors: kvaratskhelia m. PLoS Pathog. 2014 May 29;10(5):e1004171. doi: 10.1371/journal.ppat.1004171. eCollection 2014 May. PLoS Pathog. 2014. PMID: 24874515 Free PMC article.
108 results