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Sec24C is an HIV-1 host dependency factor crucial for virus replication.
Rebensburg SV, Wei G, Larue RC, Lindenberger J, Francis AC, Annamalai AS, Morrison J, Shkriabai N, Huang SW, KewalRamani V, Poeschla EM, Melikyan GB, Kvaratskhelia M. Rebensburg SV, et al. Among authors: kvaratskhelia m. Nat Microbiol. 2021 Apr;6(4):435-444. doi: 10.1038/s41564-021-00868-1. Epub 2021 Mar 1. Nat Microbiol. 2021. PMID: 33649557 Free PMC article.
Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2).
Larue R, Gupta K, Wuensch C, Shkriabai N, Kessl JJ, Danhart E, Feng L, Taltynov O, Christ F, Van Duyne GD, Debyser Z, Foster MP, Kvaratskhelia M. Larue R, et al. Among authors: kvaratskhelia m. J Biol Chem. 2012 Oct 5;287(41):34044-58. doi: 10.1074/jbc.M112.384669. Epub 2012 Aug 7. J Biol Chem. 2012. PMID: 22872640 Free PMC article.
Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes.
Eidahl JO, Crowe BL, North JA, McKee CJ, Shkriabai N, Feng L, Plumb M, Graham RL, Gorelick RJ, Hess S, Poirier MG, Foster MP, Kvaratskhelia M. Eidahl JO, et al. Among authors: kvaratskhelia m. Nucleic Acids Res. 2013 Apr 1;41(6):3924-36. doi: 10.1093/nar/gkt074. Epub 2013 Feb 8. Nucleic Acids Res. 2013. PMID: 23396443 Free PMC article.
The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.
Feng L, Sharma A, Slaughter A, Jena N, Koh Y, Shkriabai N, Larue RC, Patel PA, Mitsuya H, Kessl JJ, Engelman A, Fuchs JR, Kvaratskhelia M. Feng L, et al. Among authors: kvaratskhelia m. J Biol Chem. 2013 May 31;288(22):15813-20. doi: 10.1074/jbc.M112.443390. Epub 2013 Apr 24. J Biol Chem. 2013. PMID: 23615903 Free PMC article.
BET proteins promote efficient murine leukemia virus integration at transcription start sites.
Sharma A, Larue RC, Plumb MR, Malani N, Male F, Slaughter A, Kessl JJ, Shkriabai N, Coward E, Aiyer SS, Green PL, Wu L, Roth MJ, Bushman FD, Kvaratskhelia M. Sharma A, et al. Among authors: kvaratskhelia m. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12036-41. doi: 10.1073/pnas.1307157110. Epub 2013 Jul 1. Proc Natl Acad Sci U S A. 2013. PMID: 23818621 Free PMC article.
Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction.
Aiyer S, Swapna GV, Malani N, Aramini JM, Schneider WM, Plumb MR, Ghanem M, Larue RC, Sharma A, Studamire B, Kvaratskhelia M, Bushman FD, Montelione GT, Roth MJ. Aiyer S, et al. Among authors: kvaratskhelia m. Nucleic Acids Res. 2014 May;42(9):5917-28. doi: 10.1093/nar/gku175. Epub 2014 Mar 12. Nucleic Acids Res. 2014. PMID: 24623816 Free PMC article.
A new class of multimerization selective inhibitors of HIV-1 integrase.
Sharma A, Slaughter A, Jena N, Feng L, Kessl JJ, Fadel HJ, Malani N, Male F, Wu L, Poeschla E, Bushman FD, Fuchs JR, Kvaratskhelia M. Sharma A, et al. Among authors: kvaratskhelia m. PLoS Pathog. 2014 May 29;10(5):e1004171. doi: 10.1371/journal.ppat.1004171. eCollection 2014 May. PLoS Pathog. 2014. PMID: 24874515 Free PMC article.
108 results