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Allosteric inhibition of HIV-1 integrase activity.
Engelman A, Kessl JJ, Kvaratskhelia M. Engelman A, et al. Among authors: kvaratskhelia m. Curr Opin Chem Biol. 2013 Jun;17(3):339-45. doi: 10.1016/j.cbpa.2013.04.010. Epub 2013 May 3. Curr Opin Chem Biol. 2013. PMID: 23647983 Free PMC article. Review.
An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule.
Kessl JJ, Eidahl JO, Shkriabai N, Zhao Z, McKee CJ, Hess S, Burke TR Jr, Kvaratskhelia M. Kessl JJ, et al. Among authors: kvaratskhelia m. Mol Pharmacol. 2009 Oct;76(4):824-32. doi: 10.1124/mol.109.058883. Epub 2009 Jul 28. Mol Pharmacol. 2009. PMID: 19638533 Free PMC article.
HIV-1 Integrase-DNA Recognition Mechanisms.
Kessl JJ, McKee CJ, Eidahl JO, Shkriabai N, Katz A, Kvaratskhelia M. Kessl JJ, et al. Among authors: kvaratskhelia m. Viruses. 2009 Dec;1(3):713-36. doi: 10.3390/v1030713. Epub 2009 Nov 5. Viruses. 2009. PMID: 21994566 Free PMC article.
Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors.
Kessl JJ, Jena N, Koh Y, Taskent-Sezgin H, Slaughter A, Feng L, de Silva S, Wu L, Le Grice SF, Engelman A, Fuchs JR, Kvaratskhelia M. Kessl JJ, et al. Among authors: kvaratskhelia m. J Biol Chem. 2012 May 11;287(20):16801-11. doi: 10.1074/jbc.M112.354373. Epub 2012 Mar 21. J Biol Chem. 2012. PMID: 22437836 Free PMC article.
Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2).
Larue R, Gupta K, Wuensch C, Shkriabai N, Kessl JJ, Danhart E, Feng L, Taltynov O, Christ F, Van Duyne GD, Debyser Z, Foster MP, Kvaratskhelia M. Larue R, et al. Among authors: kvaratskhelia m. J Biol Chem. 2012 Oct 5;287(41):34044-58. doi: 10.1074/jbc.M112.384669. Epub 2012 Aug 7. J Biol Chem. 2012. PMID: 22872640 Free PMC article.
HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.
Wang H, Jurado KA, Wu X, Shun MC, Li X, Ferris AL, Smith SJ, Patel PA, Fuchs JR, Cherepanov P, Kvaratskhelia M, Hughes SH, Engelman A. Wang H, et al. Among authors: kvaratskhelia m. Nucleic Acids Res. 2012 Dec;40(22):11518-30. doi: 10.1093/nar/gks913. Epub 2012 Oct 5. Nucleic Acids Res. 2012. PMID: 23042676 Free PMC article.
108 results