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A 3D biomimetic model of lymphatics reveals cell-cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex.
Lee E, Chan SL, Lee Y, Polacheck WJ, Kwak S, Wen A, Nguyen DT, Kutys ML, Alimperti S, Kolarzyk AM, Kwak TJ, Eyckmans J, Bielenberg DR, Chen H, Chen CS. Lee E, et al. Among authors: kutys ml. Proc Natl Acad Sci U S A. 2023 Oct 10;120(41):e2308941120. doi: 10.1073/pnas.2308941120. Epub 2023 Oct 2. Proc Natl Acad Sci U S A. 2023. PMID: 37782785 Free PMC article.
Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation.
Adler FR, Anderson ARA, Bhushan A, Bogdan P, Bravo-Cordero JJ, Brock A, Chen Y, Cukierman E, DelGiorno KE, Denis GV, Ferrall-Fairbanks MC, Gartner ZJ, Germain RN, Gordon DM, Hunter G, Jolly MK, Karacosta LG, Mythreye K, Katira P, Kulkarni RP, Kutys ML, Lander AD, Laughney AM, Levine H, Lou E, Lowenstein PR, Masters KS, Pe'er D, Peyton SR, Platt MO, Purvis JE, Quon G, Richer JK, Riddle NC, Rodriguez A, Snyder JC, Lee Szeto G, Tomlin CJ, Yanai I, Zervantonakis IK, Dueck H. Adler FR, et al. Among authors: kutys ml. Cell Syst. 2023 Apr 19;14(4):252-257. doi: 10.1016/j.cels.2023.03.002. Cell Syst. 2023. PMID: 37080161 Free PMC article.
Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation.
Aw WY, Cho C, Wang H, Cooper AH, Doherty EL, Rocco D, Huang SA, Kubik S, Whitworth CP, Armstrong R, Hickey AJ, Griffith B, Kutys ML, Blatt J, Polacheck WJ. Aw WY, et al. Among authors: kutys ml. Sci Adv. 2023 Feb 15;9(7):eade8939. doi: 10.1126/sciadv.ade8939. Epub 2023 Feb 15. Sci Adv. 2023. PMID: 36791204 Free PMC article.
Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling.
Kwak M, Southard KM, Kim WR, Lin A, Kim NH, Gopalappa R, Lee HJ, An M, Choi SH, Jung Y, Noh K, Farlow J, Georgakopoulos A, Robakis NK, Kang MK, Kutys ML, Seo D, Kim HH, Kim YH, Cheon J, Gartner ZJ, Jun YW. Kwak M, et al. Among authors: kutys ml. Nat Cell Biol. 2022 Dec;24(12):1739-1753. doi: 10.1038/s41556-022-01031-6. Epub 2022 Dec 1. Nat Cell Biol. 2022. PMID: 36456828 Free PMC article.
24 results