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Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19: A case study in affinity predictions of interface variants.
MacGowan SA, Barton MI, Kutuzov M, Dushek O, van der Merwe PA, Barton GJ. MacGowan SA, et al. Among authors: kutuzov m. PLoS Comput Biol. 2022 Mar 2;18(3):e1009922. doi: 10.1371/journal.pcbi.1009922. eCollection 2022 Mar. PLoS Comput Biol. 2022. PMID: 35235558 Free PMC article.
The discriminatory power of the T cell receptor.
Pettmann J, Huhn A, Abu Shah E, Kutuzov MA, Wilson DB, Dustin ML, Davis SJ, van der Merwe PA, Dushek O. Pettmann J, et al. Elife. 2021 May 25;10:e67092. doi: 10.7554/eLife.67092. Elife. 2021. PMID: 34030769 Free PMC article.
Using CombiCells, a platform for titration and combinatorial display of cell surface ligands, to study T-cell antigen sensitivity modulation by accessory receptors.
Patel A, Andre V, Eguiguren SB, Barton MI, Burton J, Denham EM, Pettmann J, Mørch AM, Kutuzov MA, Siller-Farfán JA, Dustin ML, van der Merwe PA, Dushek O. Patel A, et al. Among authors: kutuzov ma. EMBO J. 2024 Jan;43(1):132-150. doi: 10.1038/s44318-023-00012-1. Epub 2023 Dec 18. EMBO J. 2024. PMID: 38177315 Free PMC article.
A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity.
Liu C, Zhou D, Dijokaite-Guraliuc A, Supasa P, Duyvesteyn HME, Ginn HM, Selvaraj M, Mentzer AJ, Das R, de Silva TI, Ritter TG, Plowright M, Newman TAH, Stafford L, Kronsteiner B, Temperton N, Lui Y, Fellermeyer M, Goulder P, Klenerman P, Dunachie SJ, Barton MI, Kutuzov MA, Dushek O; OPTIC Consortium; Fry EE, Mongkolsapaya J, Ren J, Stuart DI, Screaton GR. Liu C, et al. Among authors: kutuzov ma. Cell Rep Med. 2024 May 2:101553. doi: 10.1016/j.xcrm.2024.101553. Online ahead of print. Cell Rep Med. 2024. PMID: 38723626 Free article.
87 results