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Evolution-inspired engineering of nonribosomal peptide synthetases.
Bozhüyük KAJ, Präve L, Kegler C, Schenk L, Kaiser S, Schelhas C, Shi YN, Kuttenlochner W, Schreiber M, Kandler J, Alanjary M, Mohiuddin TM, Groll M, Hochberg GKA, Bode HB. Bozhüyük KAJ, et al. Among authors: kuttenlochner w. Science. 2024 Mar 22;383(6689):eadg4320. doi: 10.1126/science.adg4320. Epub 2024 Mar 22. Science. 2024. PMID: 38513038
Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A.
Illigmann A, Vielberg MT, Lakemeyer M, Wolf F, Dema T, Stange P, Kuttenlochner W, Liebhart E, Kulik A, Staudt ND, Malik I, Grond S, Sieber SA, Kaysser L, Groll M, Brötz-Oesterhelt H. Illigmann A, et al. Among authors: kuttenlochner w. Angew Chem Int Ed Engl. 2024 Jan 15;63(3):e202314028. doi: 10.1002/anie.202314028. Epub 2023 Dec 12. Angew Chem Int Ed Engl. 2024. PMID: 38029352
Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria.
Shi YM, Hirschmann M, Shi YN, Ahmed S, Abebew D, Tobias NJ, Grün P, Crames JJ, Pöschel L, Kuttenlochner W, Richter C, Herrmann J, Müller R, Thanwisai A, Pidot SJ, Stinear TP, Groll M, Kim Y, Bode HB. Shi YM, et al. Among authors: kuttenlochner w. Nat Chem. 2022 Jun;14(6):701-712. doi: 10.1038/s41557-022-00923-2. Epub 2022 Apr 25. Nat Chem. 2022. PMID: 35469007 Free PMC article.
Structural and Mechanistic Insights into C-S Bond Formation in Gliotoxin.
Scherlach K, Kuttenlochner W, Scharf DH, Brakhage AA, Hertweck C, Groll M, Huber EM. Scherlach K, et al. Among authors: kuttenlochner w. Angew Chem Int Ed Engl. 2021 Jun 14;60(25):14188-14194. doi: 10.1002/anie.202104372. Epub 2021 May 14. Angew Chem Int Ed Engl. 2021. PMID: 33909314 Free PMC article.