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Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in d-nor-nalfurafine derivatives.
Katoh K, Kutsumura N, Yamamoto N, Nagumo Y, Saitoh T, Ishikawa Y, Irukayama-Tomobe Y, Tanimura R, Yanagisawa M, Nagase H. Katoh K, et al. Among authors: kutsumura n. Bioorg Med Chem Lett. 2022 Mar 1;59:128550. doi: 10.1016/j.bmcl.2022.128550. Epub 2022 Jan 15. Bioorg Med Chem Lett. 2022. PMID: 35041942
Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists.
Nagahara T, Saitoh T, Kutsumura N, Irukayama-Tomobe Y, Ogawa Y, Kuroda D, Gouda H, Kumagai H, Fujii H, Yanagisawa M, Nagase H. Nagahara T, et al. Among authors: kutsumura n. J Med Chem. 2015 Oct 22;58(20):7931-7. doi: 10.1021/acs.jmedchem.5b00988. Epub 2015 Aug 26. J Med Chem. 2015. PMID: 26267383
Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies.
Nagase H, Yamamoto N, Yata M, Ohrui S, Okada T, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ishikawa Y, Ogawa Y, Hirayama S, Kuroda D, Watanabe Y, Gouda H, Yanagisawa M. Nagase H, et al. Among authors: kutsumura n. J Med Chem. 2017 Feb 9;60(3):1018-1040. doi: 10.1021/acs.jmedchem.6b01418. Epub 2017 Jan 18. J Med Chem. 2017. PMID: 28051300
Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor.
Yamamoto N, Ohrui S, Okada T, Yata M, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H. Yamamoto N, et al. Among authors: kutsumura n. Bioorg Med Chem Lett. 2017 Sep 1;27(17):4176-4179. doi: 10.1016/j.bmcl.2017.07.011. Epub 2017 Jul 4. Bioorg Med Chem Lett. 2017. PMID: 28739044
Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity.
Ohrui S, Yamamoto N, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H. Ohrui S, et al. Among authors: kutsumura n. Bioorg Med Chem Lett. 2018 Feb 15;28(4):774-777. doi: 10.1016/j.bmcl.2017.12.069. Epub 2017 Dec 30. Bioorg Med Chem Lett. 2018. PMID: 29338909
Favorskii-Type Rearrangement of the 4,5-Epoxymorphinan Skeleton.
Kutsumura N, Koyama Y, Suzuki Y, Tominaga KI, Yamamoto N, Saitoh T, Nagumo Y, Nagase H. Kutsumura N, et al. Org Lett. 2018 Mar 16;20(6):1559-1562. doi: 10.1021/acs.orglett.8b00288. Epub 2018 Mar 7. Org Lett. 2018. PMID: 29513016
32 results