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Sex- and age-dependent genetics of longevity in a heterogeneous mouse population.
Bou Sleiman M, Roy S, Gao AW, Sadler MC, von Alvensleben GVG, Li H, Sen S, Harrison DE, Nelson JF, Strong R, Miller RA, Kutalik Z, Williams RW, Auwerx J. Bou Sleiman M, et al. Among authors: kutalik z. Science. 2022 Sep 30;377(6614):eabo3191. doi: 10.1126/science.abo3191. Epub 2022 Sep 30. Science. 2022. PMID: 36173858 Free PMC article.
Bayesian association scan reveals loci associated with human lifespan and linked biomarkers.
McDaid AF, Joshi PK, Porcu E, Komljenovic A, Li H, Sorrentino V, Litovchenko M, Bevers RPJ, Rüeger S, Reymond A, Bochud M, Deplancke B, Williams RW, Robinson-Rechavi M, Paccaud F, Rousson V, Auwerx J, Wilson JF, Kutalik Z. McDaid AF, et al. Among authors: kutalik z. Nat Commun. 2017 Jul 27;8:15842. doi: 10.1038/ncomms15842. Nat Commun. 2017. PMID: 28748955 Free PMC article.
An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function.
Li H, Wang X, Rukina D, Huang Q, Lin T, Sorrentino V, Zhang H, Bou Sleiman M, Arends D, McDaid A, Luan P, Ziari N, Velázquez-Villegas LA, Gariani K, Kutalik Z, Schoonjans K, Radcliffe RA, Prins P, Morgenthaler S, Williams RW, Auwerx J. Li H, et al. Among authors: kutalik z. Cell Syst. 2018 Jan 24;6(1):90-102.e4. doi: 10.1016/j.cels.2017.10.016. Epub 2017 Nov 30. Cell Syst. 2018. PMID: 29199021 Free article.
Cross-species functional modules link proteostasis to human normal aging.
Komljenovic A, Li H, Sorrentino V, Kutalik Z, Auwerx J, Robinson-Rechavi M. Komljenovic A, et al. Among authors: kutalik z. PLoS Comput Biol. 2019 Jul 3;15(7):e1007162. doi: 10.1371/journal.pcbi.1007162. eCollection 2019 Jul. PLoS Comput Biol. 2019. PMID: 31269015 Free PMC article.
Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome.
Porcu E, Sadler MC, Lepik K, Auwerx C, Wood AR, Weihs A, Sleiman MSB, Ribeiro DM, Bandinelli S, Tanaka T, Nauck M, Völker U, Delaneau O, Metspalu A, Teumer A, Frayling T, Santoni FA, Reymond A, Kutalik Z. Porcu E, et al. Among authors: kutalik z. Nat Commun. 2021 Sep 24;12(1):5647. doi: 10.1038/s41467-021-25805-y. Nat Commun. 2021. PMID: 34561431 Free PMC article.
The individual and global impact of copy-number variants on complex human traits.
Auwerx C, Lepamets M, Sadler MC, Patxot M, Stojanov M, Baud D, Mägi R; Estonian Biobank Research Team; Porcu E, Reymond A, Kutalik Z. Auwerx C, et al. Among authors: kutalik z. Am J Hum Genet. 2022 Apr 7;109(4):647-668. doi: 10.1016/j.ajhg.2022.02.010. Epub 2022 Mar 2. Am J Hum Genet. 2022. PMID: 35240056 Free PMC article.
317 results