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Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract.
Kon R, Ikarashi N, Nagoya C, Takayama T, Kusunoki Y, Ishii M, Ueda H, Ochiai W, Machida Y, Sugita K, Sugiyama K. Kon R, et al. Among authors: kusunoki y. J Ethnopharmacol. 2014 Feb 27;152(1):190-200. doi: 10.1016/j.jep.2013.12.055. Epub 2014 Jan 8. J Ethnopharmacol. 2014. PMID: 24412547
Effects of menthol on the pharmacokinetics of triazolam and phenytoin.
Hoshino M, Ikarashi N, Hirobe R, Hayashi M, Hiraoka H, Yokobori K, Ochiai T, Kusunoki Y, Kon R, Tajima M, Ochiai W, Sugiyama K. Hoshino M, et al. Among authors: kusunoki y. Biol Pharm Bull. 2015;38(3):454-60. doi: 10.1248/bpb.b14-00764. Epub 2015 Jan 14. Biol Pharm Bull. 2015. PMID: 25757928 Free article.
Mice with neuropathic pain exhibit morphine tolerance due to a decrease in the morphine concentration in the brain.
Ochiai W, Kaneta M, Nagae M, Yuzuhara A, Li X, Suzuki H, Hanagata M, Kitaoka S, Suto W, Kusunoki Y, Kon R, Miyashita K, Masukawa D, Ikarashi N, Narita M, Suzuki T, Sugiyama K. Ochiai W, et al. Among authors: kusunoki y. Eur J Pharm Sci. 2016 Sep 20;92:298-304. doi: 10.1016/j.ejps.2016.03.019. Epub 2016 Apr 18. Eur J Pharm Sci. 2016. PMID: 27102159
438 results