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Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis.
Chen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Gujja S, Cilfone NA, Kauffman KJ, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson DG, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwartz MA, Pober JS, Chittenden TW, Tellides G, Simons M. Chen PY, et al. Among authors: kusters p. Nat Metab. 2019 Sep;1(9):912-926. doi: 10.1038/s42255-019-0102-3. Epub 2019 Aug 26. Nat Metab. 2019. PMID: 31572976 Free PMC article.
Diet-induced obesity in mice diminishes hematopoietic stem and progenitor cells in the bone marrow.
van den Berg SM, Seijkens TT, Kusters PJ, Beckers L, den Toom M, Smeets E, Levels J, de Winther MP, Lutgens E. van den Berg SM, et al. Among authors: kusters pj. FASEB J. 2016 May;30(5):1779-88. doi: 10.1096/fj.201500175. Epub 2016 Jan 26. FASEB J. 2016. PMID: 26813974
This implies that the effects of obesity on HSPCs hampers proper functioning of the immune system.-Van den Berg, S. M., Seijkens, T. T. P., Kusters, P. J. H., Beckers, L., den Toom, M., Smeets, E., Levels, J., de Winther, M. P. J., Lutgens, E. Diet-ind …
This implies that the effects of obesity on HSPCs hampers proper functioning of the immune system.-Van den Berg, S. M., Seijkens, T. T. P …
Constitutive CD40 Signaling in Dendritic Cells Limits Atherosclerosis by Provoking Inflammatory Bowel Disease and Ensuing Cholesterol Malabsorption.
Kusters P, Seijkens T, Bürger C, Legein B, Winkels H, Gijbels M, Barthels C, Bennett R, Beckers L, Atzler D, Biessen E, Brocker T, Weber C, Gerdes N, Lutgens E. Kusters P, et al. Am J Pathol. 2017 Dec;187(12):2912-2919. doi: 10.1016/j.ajpath.2017.08.016. Epub 2017 Sep 19. Am J Pathol. 2017. PMID: 28935569 Free article.
CD40L Deficiency Protects Against Aneurysm Formation.
Kusters PJH, Seijkens TTP, Beckers L, Lievens D, Winkels H, de Waard V, Duijvestijn A, Lindquist Liljeqvist M, Roy J, Daugherty A, Newby A, Gerdes N, Lutgens E. Kusters PJH, et al. Arterioscler Thromb Vasc Biol. 2018 May;38(5):1076-1085. doi: 10.1161/ATVBAHA.117.310640. Epub 2018 Mar 8. Arterioscler Thromb Vasc Biol. 2018. PMID: 29519940
Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis.
Aarts SA, Seijkens TT, Kusters PJ, van Tiel CM, Reiche ME, den Toom M, Beckers L, van Roomen CP, de Winther MP, Kooij G, Lutgens E. Aarts SA, et al. Among authors: kusters pj. J Pathol. 2019 Apr;247(4):471-480. doi: 10.1002/path.5205. Epub 2019 Jan 30. J Pathol. 2019. PMID: 30471110 Free PMC article.
The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease.
Bosmans LA, Bosch L, Kusters PJH, Lutgens E, Seijkens TTP. Bosmans LA, et al. Among authors: kusters pjh. J Cardiovasc Transl Res. 2021 Feb;14(1):13-22. doi: 10.1007/s12265-020-09994-3. Epub 2020 Mar 28. J Cardiovasc Transl Res. 2021. PMID: 32222950 Free PMC article. Review.
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