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Biomolecular condensate phase diagrams with a combinatorial microdroplet platform.
Arter WE, Qi R, Erkamp NA, Krainer G, Didi K, Welsh TJ, Acker J, Nixon-Abell J, Qamar S, Guillén-Boixet J, Franzmann TM, Kuster D, Hyman AA, Borodavka A, George-Hyslop PS, Alberti S, Knowles TPJ. Arter WE, et al. Among authors: kuster d. Nat Commun. 2022 Dec 21;13(1):7845. doi: 10.1038/s41467-022-35265-7. Nat Commun. 2022. PMID: 36543777 Free PMC article.
Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates.
Yan X, Kuster D, Mohanty P, Nijssen J, Pombo-García K, Rizuan A, Franzmann TM, Sergeeva A, Passos PM, George L, Wang SH, Shenoy J, Danielson HL, Honigmann A, Ayala YM, Fawzi NL, Mittal J, Alberti S, Hyman AA. Yan X, et al. Among authors: kuster d. bioRxiv [Preprint]. 2024 Jan 24:2024.01.23.576837. doi: 10.1101/2024.01.23.576837. bioRxiv. 2024. PMID: 38328053 Free PMC article. Preprint.
Nuclear actin polymerization rapidly mediates replication fork remodeling upon stress by limiting PrimPol activity.
Palumbieri MD, Merigliano C, González-Acosta D, Kuster D, Krietsch J, Stoy H, von Känel T, Ulferts S, Welter B, Frey J, Doerdelmann C, Sanchi A, Grosse R, Chiolo I, Lopes M. Palumbieri MD, et al. Among authors: kuster d. Nat Commun. 2023 Nov 28;14(1):7819. doi: 10.1038/s41467-023-43183-5. Nat Commun. 2023. PMID: 38016948 Free PMC article.
Geranylgeranylacetone reduces cardiomyocyte stiffness and attenuates diastolic dysfunction in a rat model of cardiometabolic syndrome.
Waddingham MT, Sequeira V, Kuster DWD, Dal Canto E, Handoko ML, de Man FS, da Silva Gonçalves Bós D, Ottenheijm CA, Shen S, van der Pijl RJ, van der Velden J, Paulus WJ, Eringa EC. Waddingham MT, et al. Among authors: kuster dwd. Physiol Rep. 2023 Nov;11(22):e15788. doi: 10.14814/phy2.15788. Physiol Rep. 2023. PMID: 37985159 Free PMC article. Clinical Trial.
DWORF Extends Life Span in a PLN-R14del Cardiomyopathy Mouse Model by Reducing Abnormal Sarcoplasmic Reticulum Clusters.
Stege NM, Eijgenraam TR, Oliveira Nunes Teixeira V, Feringa AM, Schouten EM, Kuster DWD, van der Velden J, Wolters AHG, Giepmans BNG, Makarewich CA, Bassel-Duby R, Olson EN, de Boer RA, Silljé HHW. Stege NM, et al. Among authors: kuster dwd. Circ Res. 2023 Dec 8;133(12):1006-1021. doi: 10.1161/CIRCRESAHA.123.323304. Epub 2023 Nov 13. Circ Res. 2023. PMID: 37955153 Free PMC article.
151 results