Kuscu C - Search Results

1

CRISPR-STOP: gene silencing through base-editing-induced nonsense mutations.

Kuscu C, Parlak M, Tufan T, Yang J, Szlachta K, Wei X, Mammadov R, Adli M. Kuscu C, et al. Nat Methods. 2017 Jul;14(7):710-712. doi: 10.1038/nmeth.4327. Epub 2017 Jun 5. Nat Methods. 2017. PMID: 28581493

2

CRISPR-Cas9-AID base editor is a powerful gain-of-function screening tool.

Kuscu C, Adli M. Kuscu C, et al. Nat Methods. 2016 Nov 29;13(12):983-984. doi: 10.1038/nmeth.4076. Nat Methods. 2016. PMID: 27898061 No abstract available.

3

Live cell imaging of low- and non-repetitive chromosome loci using CRISPR-Cas9.

Qin P, Parlak M, Kuscu C, Bandaria J, Mir M, Szlachta K, Singh R, Darzacq X, Yildiz A, Adli M. Qin P, et al. Among authors: kuscu c. Nat Commun. 2017 Mar 14;8:14725. doi: 10.1038/ncomms14725. Nat Commun. 2017. PMID: 28290446 Free PMC article.

4

Temporal and Spatial Epigenome Editing Allows Precise Gene Regulation in Mammalian Cells.

Kuscu C, Mammadov R, Czikora A, Unlu H, Tufan T, Fischer NL, Arslan S, Bekiranov S, Kanemaki M, Adli M. Kuscu C, et al. J Mol Biol. 2019 Jan 4;431(1):111-121. doi: 10.1016/j.jmb.2018.08.001. Epub 2018 Aug 9. J Mol Biol. 2019. PMID: 30098338

5

CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response.

Szlachta K, Kuscu C, Tufan T, Adair SJ, Shang S, Michaels AD, Mullen MG, Fischer NL, Yang J, Liu L, Trivedi P, Stelow EB, Stukenberg PT, Parsons JT, Bauer TW, Adli M. Szlachta K, et al. Among authors: kuscu c. Nat Commun. 2018 Oct 15;9(1):4275. doi: 10.1038/s41467-018-06676-2. Nat Commun. 2018. PMID: 30323222 Free PMC article.

6

Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease.

Kuscu C, Arslan S, Singh R, Thorpe J, Adli M. Kuscu C, et al. Nat Biotechnol. 2014 Jul;32(7):677-83. doi: 10.1038/nbt.2916. Epub 2014 May 18. Nat Biotechnol. 2014. PMID: 24837660

7

Recurrent mutations at estrogen receptor binding sites alter chromatin topology and distal gene expression in breast cancer.

Yang J, Wei X, Tufan T, Kuscu C, Unlu H, Farooq S, Demirtas E, Paschal BM, Adli M. Yang J, et al. Among authors: kuscu c. Genome Biol. 2018 Nov 7;19(1):190. doi: 10.1186/s13059-018-1572-4. Genome Biol. 2018. PMID: 30404658 Free PMC article.

8

Targeted CRISPR screening identifies PRMT5 as synthetic lethality combinatorial target with gemcitabine in pancreatic cancer cells.

Wei X, Yang J, Adair SJ, Ozturk H, Kuscu C, Lee KY, Kane WJ, O'Hara PE, Liu D, Demirlenk YM, Habieb AH, Yilmaz E, Dutta A, Bauer TW, Adli M. Wei X, et al. Among authors: kuscu c. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28068-28079. doi: 10.1073/pnas.2009899117. Epub 2020 Oct 23. Proc Natl Acad Sci U S A. 2020. PMID: 33097661 Free PMC article.

9

ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer.

Ozturk H, Cingoz H, Tufan T, Yang J, Adair SJ, Tummala KS, Kuscu C, Kinali M, Comertpay G, Nagdas S, Goudreau BJ, Luleyap HU, Bingul Y, Ware TB, Hwang WL, Hsu KL, Kashatus DF, Ting DT, Chandel NS, Bardeesy N, Bauer TW, Adli M. Ozturk H, et al. Among authors: kuscu c. Dev Cell. 2022 Jun 6;57(11):1331-1346.e9. doi: 10.1016/j.devcel.2022.04.014. Epub 2022 May 3. Dev Cell. 2022. PMID: 35508175 Free article.

10

Cas9-chromatin binding information enables more accurate CRISPR off-target prediction.

Singh R, Kuscu C, Quinlan A, Qi Y, Adli M. Singh R, et al. Among authors: kuscu c. Nucleic Acids Res. 2015 Oct 15;43(18):e118. doi: 10.1093/nar/gkv575. Epub 2015 Jun 1. Nucleic Acids Res. 2015. PMID: 26032770 Free PMC article.

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