Kurz T - Search Results

1

In Vitro Assessment of the Genotoxic Hazard of Novel Hydroxamic Acid- and Benzamide-Type Histone Deacetylase Inhibitors (HDACi).

Friedrich A, Assmann AS, Schumacher L, Stuijvenberg JV, Kassack MU, Schulz WA, Roos WP, Hansen FK, Pflieger M, Kurz T, Fritz G. Friedrich A, et al. Among authors: kurz t. Int J Mol Sci. 2020 Jul 3;21(13):4747. doi: 10.3390/ijms21134747. Int J Mol Sci. 2020. PMID: 32635356 Free PMC article.

2

Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells.

Marek L, Hamacher A, Hansen FK, Kuna K, Gohlke H, Kassack MU, Kurz T. Marek L, et al. Among authors: kurz t. J Med Chem. 2013 Jan 24;56(2):427-36. doi: 10.1021/jm301254q. Epub 2013 Jan 8. J Med Chem. 2013. PMID: 23252603

3

Design, synthesis, and conformational analysis of trispyrimidonamides as α-helix mimetics.

Spanier L, Ciglia E, Hansen FK, Kuna K, Frank W, Gohlke H, Kurz T. Spanier L, et al. Among authors: kurz t. J Org Chem. 2014 Feb 21;79(4):1582-93. doi: 10.1021/jo402353z. Epub 2014 Jan 31. J Org Chem. 2014. PMID: 24447208

4

Synthesis, antimalarial properties, and SAR studies of alkoxyurea-based HDAC inhibitors.

Hansen FK, Skinner-Adams TS, Duffy S, Marek L, Sumanadasa SD, Kuna K, Held J, Avery VM, Andrews KT, Kurz T. Hansen FK, et al. Among authors: kurz t. ChemMedChem. 2014 Mar;9(3):665-70. doi: 10.1002/cmdc.201300469. Epub 2014 Feb 4. ChemMedChem. 2014. PMID: 24497437

5

Lysine acetylation in sexual stage malaria parasites is a target for antimalarial small molecules.

Trenholme K, Marek L, Duffy S, Pradel G, Fisher G, Hansen FK, Skinner-Adams TS, Butterworth A, Ngwa CJ, Moecking J, Goodman CD, McFadden GI, Sumanadasa SD, Fairlie DP, Avery VM, Kurz T, Andrews KT. Trenholme K, et al. Among authors: kurz t. Antimicrob Agents Chemother. 2014 Jul;58(7):3666-78. doi: 10.1128/AAC.02721-13. Epub 2014 Apr 14. Antimicrob Agents Chemother. 2014. PMID: 24733477 Free PMC article.

6

Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages.

Hansen FK, Sumanadasa SD, Stenzel K, Duffy S, Meister S, Marek L, Schmetter R, Kuna K, Hamacher A, Mordmüller B, Kassack MU, Winzeler EA, Avery VM, Andrews KT, Kurz T. Hansen FK, et al. Among authors: kurz t. Eur J Med Chem. 2014 Jul 23;82:204-13. doi: 10.1016/j.ejmech.2014.05.050. Epub 2014 May 22. Eur J Med Chem. 2014. PMID: 24904967 Free PMC article.

7

Histone deacetylase inhibition attenuates cardiac hypertrophy and fibrosis through acetylation of mineralocorticoid receptor in spontaneously hypertensive rats.

Kang SH, Seok YM, Song MJ, Lee HA, Kurz T, Kim I. Kang SH, et al. Among authors: kurz t. Mol Pharmacol. 2015 May;87(5):782-91. doi: 10.1124/mol.114.096974. Epub 2015 Feb 9. Mol Pharmacol. 2015. PMID: 25667225

8

HDAC5 controls the functions of Foxp3(+) T-regulatory and CD8(+) T cells.

Xiao H, Jiao J, Wang L, O'Brien S, Newick K, Wang LC, Falkensammer E, Liu Y, Han R, Kapoor V, Hansen FK, Kurz T, Hancock WW, Beier UH. Xiao H, et al. Among authors: kurz t. Int J Cancer. 2016 May 15;138(10):2477-86. doi: 10.1002/ijc.29979. Epub 2016 Jan 19. Int J Cancer. 2016. PMID: 26704363 Free PMC article.

9

Rational design and diversity-oriented synthesis of peptoid-based selective HDAC6 inhibitors.

Diedrich D, Hamacher A, Gertzen CG, Alves Avelar LA, Reiss GJ, Kurz T, Gohlke H, Kassack MU, Hansen FK. Diedrich D, et al. Among authors: kurz t. Chem Commun (Camb). 2016 Feb 21;52(15):3219-22. doi: 10.1039/c5cc10301k. Chem Commun (Camb). 2016. PMID: 26810607

10

Class I HDACs specifically regulate E-cadherin expression in human renal epithelial cells.

Choi SY, Kee HJ, Kurz T, Hansen FK, Ryu Y, Kim GR, Lin MQ, Jin L, Piao ZH, Jeong MH. Choi SY, et al. Among authors: kurz t. J Cell Mol Med. 2016 Dec;20(12):2289-2298. doi: 10.1111/jcmm.12919. Epub 2016 Jul 15. J Cell Mol Med. 2016. PMID: 27420561 Free PMC article.

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