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Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity.
J Med Chem. 2020 Dec 10;63(23):14805-14820. doi: 10.1021/acs.jmedchem.0c01215. Epub 2020 Nov 19.
J Med Chem. 2020.
PMID: 33210531
Discovery of a potent dual inhibitor of wild-type and mutant respiratory syncytial virus fusion proteins through the modulation of atropisomer interconversion properties.
Yamaguchi-Sasaki T, Kawaguchi T, Okada A, Tokura S, Tanaka-Yamamoto N, Takeuchi T, Ogata Y, Takahashi R, Kurimoto-Tsuruta R, Tamaoki T, Sugaya Y, Abe-Kumasaka T, Arikawa K, Yoshida I, Sugiyama H, Kanuma K, Yoshinaga M.
Yamaguchi-Sasaki T, et al. Among authors: kurimoto tsuruta r.
Bioorg Med Chem. 2020 Dec 15;28(24):115818. doi: 10.1016/j.bmc.2020.115818. Epub 2020 Oct 31.
Bioorg Med Chem. 2020.
PMID: 33190073
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Lead optimization of 2-hydroxymethyl imidazoles as non-hydroxamate LpxC inhibitors: Discovery of TP0586532.
Ushiyama F, Takashima H, Matsuda Y, Ogata Y, Sasamoto N, Kurimoto-Tsuruta R, Ueki K, Tanaka-Yamamoto N, Endo M, Mima M, Fujita K, Takata I, Tsuji S, Yamashita H, Okumura H, Otake K, Sugiyama H.
Ushiyama F, et al. Among authors: kurimoto tsuruta r.
Bioorg Med Chem. 2021 Jan 15;30:115964. doi: 10.1016/j.bmc.2020.115964. Epub 2020 Dec 29.
Bioorg Med Chem. 2021.
PMID: 33385955
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