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Synthesis and study of new paramagnetic and diamagnetic verapamil derivatives.
Bognár B, Ahmed S, Kuppusamy ML, Selvendiran K, Khan M, Jeko J, Hankovszky OH, Kálai T, Kuppusamy P, Hideg K. Bognár B, et al. Among authors: kuppusamy ml, kuppusamy p. Bioorg Med Chem. 2010 Apr 15;18(8):2954-63. doi: 10.1016/j.bmc.2010.02.040. Epub 2010 Feb 25. Bioorg Med Chem. 2010. PMID: 20347319 Free PMC article.
The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53.
Madan E, Parker TM, Bauer MR, Dhiman A, Pelham CJ, Nagane M, Kuppusamy ML, Holmes M, Holmes TR, Shaik K, Shee K, Kiparoidze S, Smith SD, Park YA, Gomm JJ, Jones LJ, Tomás AR, Cunha AC, Selvendiran K, Hansen LA, Fersht AR, Hideg K, Gogna R, Kuppusamy P. Madan E, et al. Among authors: kuppusamy ml. J Biol Chem. 2018 Mar 23;293(12):4262-4276. doi: 10.1074/jbc.RA117.000950. Epub 2018 Jan 30. J Biol Chem. 2018. PMID: 29382728 Free PMC article.
Selective Induction of Cellular Toxicity and Anti-tumor Efficacy by N-Methylpiperazinyl Diarylidenylpiperidone and its Pro-nitroxide Conjugate through ROS-mediated Mitochondrial Dysfunction and G2/M Cell-cycle Arrest in Human Pancreatic Cancer.
Mast JM, Hinds JW, Tse D, Axelrod K, Kuppusamy ML, Kmiec MM, Bognár B, Kálai T, Kuppusamy P. Mast JM, et al. Among authors: kuppusamy ml. Cell Biochem Biophys. 2020 Jun;78(2):191-202. doi: 10.1007/s12013-020-00919-0. Epub 2020 May 24. Cell Biochem Biophys. 2020. PMID: 32449075
Safe and targeted anticancer efficacy of a novel class of antioxidant-conjugated difluorodiarylidenyl piperidones: differential cytotoxicity in healthy and cancer cells.
Selvendiran K, Ahmed S, Dayton A, Kuppusamy ML, Tazi M, Bratasz A, Tong L, Rivera BK, Kálai T, Hideg K, Kuppusamy P. Selvendiran K, et al. Among authors: kuppusamy ml, kuppusamy p. Free Radic Biol Med. 2010 May 1;48(9):1228-35. doi: 10.1016/j.freeradbiomed.2010.02.009. Epub 2010 Feb 12. Free Radic Biol Med. 2010. PMID: 20156552 Free PMC article.
37 results