Kuo SC - Search Results

1

Diarylheptanoid 35d overcomes EGFR TKI resistance by inducing hsp70-mediated lysosomal degradation of EGFR in EGFR-mutant lung adenocarcinoma.

Hong X, Hsieh MT, Tseng TY, Lin HY, Chang HC, Yau ST, Cheng WC, Ke B, Liao HH, Wu CY, Liu AA, Wu MM, Huang KY, Yang PC, Kuo SC, Hung MC, Lee PC. Hong X, et al. Among authors: kuo sc. J Biol Chem. 2023 Jun;299(6):104814. doi: 10.1016/j.jbc.2023.104814. Epub 2023 May 11. J Biol Chem. 2023. PMID: 37178919 Free PMC article.

2

Synthesis of 1-benzyl-3-(5-hydroxymethyl-2-furyl)selenolo[3,2-c]pyrazole derivatives as new anticancer agents.

Chou LC, Huang LJ, Hsu MH, Fang MC, Yang JS, Zhuang SH, Lin HY, Lee FY, Teng CM, Kuo SC. Chou LC, et al. Among authors: kuo sc. Eur J Med Chem. 2010 Apr;45(4):1395-402. doi: 10.1016/j.ejmech.2009.12.039. Epub 2010 Jan 4. Eur J Med Chem. 2010. PMID: 20097456

3

Design, synthesis, and preclinical evaluation of new 5,6- (or 6,7-) disubstituted-2-(fluorophenyl)quinolin-4-one derivatives as potent antitumor agents.

Chou LC, Tsai MT, Hsu MH, Wang SH, Way TD, Huang CH, Lin HY, Qian K, Dong Y, Lee KH, Huang LJ, Kuo SC. Chou LC, et al. Among authors: kuo sc. J Med Chem. 2010 Nov 25;53(22):8047-58. doi: 10.1021/jm100780c. Epub 2010 Oct 25. J Med Chem. 2010. PMID: 20973552

4

The novel synthesized 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) compound induces G2/M phase arrest and mitochondrial-dependent apoptotic cell death through inhibition of CDK1 and AKT activity in HL-60 human leukemia cells.

Huang SM, Yang JS, Tsai SC, Chen MH, Hsu MH, Lin HY, Chou LC, Chinag JH, Lee KH, Huang LJ, Kuo SC. Huang SM, et al. Among authors: kuo sc. Int J Oncol. 2011 May;38(5):1357-64. doi: 10.3892/ijo.2011.952. Epub 2011 Feb 22. Int J Oncol. 2011. PMID: 21344160

5

CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells.

Lee JC, Chou LC, Huang CH, Chung JG, Huang LJ, Lee KH, Hung MC, Way TD, Kuo SC. Lee JC, et al. Among authors: kuo sc. Eur J Pharmacol. 2011 Nov 16;670(1):96-104. doi: 10.1016/j.ejphar.2011.08.006. Epub 2011 Sep 3. Eur J Pharmacol. 2011. PMID: 21907193

6

Palladium(II) acetate mediated oxidative cyclization of ω-unsaturated α-cyano ketones for facile construction of methylenecyclohexane ring system.

Hsieh MT, Shia KS, Liu HJ, Kuo SC. Hsieh MT, et al. Among authors: kuo sc. Org Biomol Chem. 2012 Jun 21;10(23):4609-17. doi: 10.1039/c2ob25161b. Epub 2012 May 14. Org Biomol Chem. 2012. PMID: 22581281

7

Inhibition of formyl peptide-stimulated superoxide anion generation by Fal-002-2 occurs mainly through the blockade of the p21-activated kinase and protein kinase C signaling pathways in ratneutrophils.

Tsai YR, Huang LJ, Lin HY, Hung YJ, Lee MR, Kuo SC, Hsu MF, Wang JP. Tsai YR, et al. Among authors: kuo sc. Eur J Pharmacol. 2013 Feb 15;701(1-3):114-23. doi: 10.1016/j.ejphar.2013.01.015. Epub 2013 Jan 25. Eur J Pharmacol. 2013. PMID: 23357556

8

Inhibition of formyl peptide-stimulated phospholipase D activation by Fal-002-2 via blockade of the Arf6, RhoA and protein kinase C signaling pathways in rat neutrophils.

Tsai YR, Huang LJ, Lin HY, Hung YJ, Lee MR, Kuo SC, Hsu MF, Wang JP. Tsai YR, et al. Among authors: kuo sc. Naunyn Schmiedebergs Arch Pharmacol. 2013 Jun;386(6):507-19. doi: 10.1007/s00210-013-0851-6. Epub 2013 Mar 23. Naunyn Schmiedebergs Arch Pharmacol. 2013. PMID: 23525454

9

Synthesis and anticancer activity of 2,4-disubstituted furo[3,2-b]indole derivatives.

Zhuang SH, Lin YC, Chou LC, Hsu MH, Lin HY, Huang CH, Lien JC, Kuo SC, Huang LJ. Zhuang SH, et al. Among authors: kuo sc. Eur J Med Chem. 2013 Aug;66:466-79. doi: 10.1016/j.ejmech.2013.06.012. Epub 2013 Jun 18. Eur J Med Chem. 2013. PMID: 23831809

10

Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead.

Cheng YY, Liu CY, Tsai MT, Lin HY, Yang JS, Wu TS, Kuo SC, Huang LJ, Lee KH. Cheng YY, et al. Among authors: kuo sc. Bioorg Med Chem Lett. 2013 Sep 15;23(18):5223-7. doi: 10.1016/j.bmcl.2013.06.083. Epub 2013 Jul 4. Bioorg Med Chem Lett. 2013. PMID: 23916255 Free PMC article.

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