Kunzelmann S - Search Results

1

Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors.

Fugger K, Bajrami I, Silva Dos Santos M, Young SJ, Kunzelmann S, Kelly G, Hewitt G, Patel H, Goldstone R, Carell T, Boulton SJ, MacRae J, Taylor IA, West SC. Fugger K, et al. Among authors: kunzelmann s. Science. 2021 Apr 9;372(6538):156-165. doi: 10.1126/science.abb4542. Science. 2021. PMID: 33833118 Free PMC article.

2

A continuous enzyme-coupled assay for triphosphohydrolase activity of HIV-1 restriction factor SAMHD1.

Arnold LH, Kunzelmann S, Webb MR, Taylor IA. Arnold LH, et al. Among authors: kunzelmann s. Antimicrob Agents Chemother. 2015 Jan;59(1):186-92. doi: 10.1128/AAC.03903-14. Epub 2014 Oct 20. Antimicrob Agents Chemother. 2015. PMID: 25331707 Free PMC article.

3

Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction.

Arnold LH, Groom HC, Kunzelmann S, Schwefel D, Caswell SJ, Ordonez P, Mann MC, Rueschenbaum S, Goldstone DC, Pennell S, Howell SA, Stoye JP, Webb M, Taylor IA, Bishop KN. Arnold LH, et al. Among authors: kunzelmann s. PLoS Pathog. 2015 Oct 2;11(10):e1005194. doi: 10.1371/journal.ppat.1005194. eCollection 2015 Oct. PLoS Pathog. 2015. PMID: 26431200 Free PMC article.

4

SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells.

Ordonez P, Kunzelmann S, Groom HC, Yap MW, Weising S, Meier C, Bishop KN, Taylor IA, Stoye JP. Ordonez P, et al. Among authors: kunzelmann s. Sci Rep. 2017 Feb 21;7:42824. doi: 10.1038/srep42824. Sci Rep. 2017. PMID: 28220857 Free PMC article.

5

The speed of GTP hydrolysis determines GTP cap size and controls microtubule stability.

Roostalu J, Thomas C, Cade NI, Kunzelmann S, Taylor IA, Surrey T. Roostalu J, et al. Among authors: kunzelmann s. Elife. 2020 Feb 13;9:e51992. doi: 10.7554/eLife.51992. Elife. 2020. PMID: 32053491 Free PMC article.

6

Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.

Morris ER, Caswell SJ, Kunzelmann S, Arnold LH, Purkiss AG, Kelly G, Taylor IA. Morris ER, et al. Among authors: kunzelmann s. Nat Commun. 2020 Jun 23;11(1):3165. doi: 10.1038/s41467-020-16983-2. Nat Commun. 2020. PMID: 32576829 Free PMC article.

7

Structural characterisation of the Chaetomium thermophilum Chl1 helicase.

Hodáková Z, Nans A, Kunzelmann S, Mehmood S, Taylor I, Uhlmann F, Cherepanov P, Singleton MR. Hodáková Z, et al. Among authors: kunzelmann s. PLoS One. 2021 May 10;16(5):e0251261. doi: 10.1371/journal.pone.0251261. eCollection 2021. PLoS One. 2021. PMID: 33970942 Free PMC article.

8

Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of R_p- and S_p-dNTPαS Diastereomers.

Morris ER, Kunzelmann S, Caswell SJ, Purkiss AG, Kelly G, Taylor IA. Morris ER, et al. Among authors: kunzelmann s. Biochemistry. 2021 Jun 1;60(21):1682-1698. doi: 10.1021/acs.biochem.0c00944. Epub 2021 May 14. Biochemistry. 2021. PMID: 33988981 Free PMC article.

9

Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor.

Greenhough LA, Liang CC, Belan O, Kunzelmann S, Maslen S, Rodrigo-Brenni MC, Anand R, Skehel M, Boulton SJ, West SC. Greenhough LA, et al. Among authors: kunzelmann s. Nature. 2023 Jul;619(7970):650-657. doi: 10.1038/s41586-023-06179-1. Epub 2023 Jun 21. Nature. 2023. PMID: 37344587 Free PMC article.

10

Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1.

Rzechorzek NJ, Kunzelmann S, Purkiss AG, Silva Dos Santos M, MacRae JI, Taylor IA, Fugger K, West SC. Rzechorzek NJ, et al. Among authors: kunzelmann s. Nat Commun. 2023 Oct 26;14(1):6809. doi: 10.1038/s41467-023-42544-4. Nat Commun. 2023. PMID: 37884503 Free PMC article.

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