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Blocking FSH induces thermogenic adipose tissue and reduces body fat.
Liu P, Ji Y, Yuen T, Rendina-Ruedy E, DeMambro VE, Dhawan S, Abu-Amer W, Izadmehr S, Zhou B, Shin AC, Latif R, Thangeswaran P, Gupta A, Li J, Shnayder V, Robinson ST, Yu YE, Zhang X, Yang F, Lu P, Zhou Y, Zhu LL, Oberlin DJ, Davies TF, Reagan MR, Brown A, Kumar TR, Epstein S, Iqbal J, Avadhani NG, New MI, Molina H, van Klinken JB, Guo EX, Buettner C, Haider S, Bian Z, Sun L, Rosen CJ, Zaidi M. Liu P, et al. Among authors: kumar tr. Nature. 2017 Jun 1;546(7656):107-112. doi: 10.1038/nature22342. Epub 2017 May 24. Nature. 2017. PMID: 28538730 Free PMC article.
First-in-class humanized FSH blocking antibody targets bone and fat.
Gera S, Sant D, Haider S, Korkmaz F, Kuo TC, Mathew M, Perez-Pena H, Xie H, Chen H, Batista R, Ma K, Cheng Z, Hadelia E, Robinson C, Macdonald A, Miyashita S, Williams A, Jebian G, Miyashita H, Gumerova A, Ievleva K, Smith P, He J, Ryu V, DeMambro V, Quinn MA, Meseck M, Kim SM, Kumar TR, Iqbal J, New MI, Lizneva D, Rosen CJ, Hsueh AJ, Yuen T, Zaidi M. Gera S, et al. Among authors: kumar tr. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):28971-28979. doi: 10.1073/pnas.2014588117. Epub 2020 Oct 30. Proc Natl Acad Sci U S A. 2020. PMID: 33127753 Free PMC article.
FSH directly regulates bone mass.
Sun L, Peng Y, Sharrow AC, Iqbal J, Zhang Z, Papachristou DJ, Zaidi S, Zhu LL, Yaroslavskiy BB, Zhou H, Zallone A, Sairam MR, Kumar TR, Bo W, Braun J, Cardoso-Landa L, Schaffler MB, Moonga BS, Blair HC, Zaidi M. Sun L, et al. Among authors: kumar tr. Cell. 2006 Apr 21;125(2):247-60. doi: 10.1016/j.cell.2006.01.051. Cell. 2006. PMID: 16630814 Free article.
Proresorptive actions of FSH and bone loss.
Zaidi M, Blair HC, Iqbal J, Zhu LL, Kumar TR, Zallone A, Sun L. Zaidi M, et al. Among authors: kumar tr. Ann N Y Acad Sci. 2007 Nov;1116:376-82. doi: 10.1196/annals.1402.056. Ann N Y Acad Sci. 2007. PMID: 18083939 Review.
Effects of follicle-stimulating hormone on energy balance and tissue metabolic health after loss of ovarian function.
Libby AE, Solt CM, Jackman MR, Sherk VD, Foright RM, Johnson GC, Nguyen TT, Breit MJ, Hulett N, Rudolph MC, Roberson PA, Wellberg EA, Jambal P, Scalzo RL, Higgins J, Kumar TR, Wierman ME, Pan Z, Shankar K, Klemm DJ, Moreau KL, Kohrt WM, MacLean PS. Libby AE, et al. Among authors: kumar tr. Am J Physiol Endocrinol Metab. 2024 May 1;326(5):E626-E639. doi: 10.1152/ajpendo.00400.2023. Epub 2024 Mar 27. Am J Physiol Endocrinol Metab. 2024. PMID: 38536037
An interview with Dr. Daniel Johnston.
Kumar TR. Kumar TR. Biol Reprod. 2024 Feb 1:ioae021. doi: 10.1093/biolre/ioae021. Online ahead of print. Biol Reprod. 2024. PMID: 38302090 No abstract available.
181 results