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ATR inhibition augments the efficacy of lurbinectedin in small-cell lung cancer.
Schultz CW, Zhang Y, Elmeskini R, Zimmermann A, Fu H, Murai Y, Wangsa D, Kumar S, Takahashi N, Atkinson D, Saha LK, Lee CF, Elenbaas B, Desai P, Sebastian R, Sharma AK, Abel M, Schroeder B, Krishnamurthy M, Kumar R, Roper N, Aladjem M, Zenke FT, Ohler ZW, Pommier Y, Thomas A. Schultz CW, et al. Among authors: kumar s, kumar r. EMBO Mol Med. 2023 Aug 7;15(8):e17313. doi: 10.15252/emmm.202217313. Epub 2023 Jul 25. EMBO Mol Med. 2023. PMID: 37491889 Free PMC article.
Dynamics of genomic and immune responses during primary immunotherapy resistance in mismatch repair-deficient tumors.
Takahashi N, Rajapakse VN, Pongor L, Kumar S, Tlemsani C, Erwin-Cohen R, Young HA, Hewitt S, Wei JS, Khan J, Villarino AV, Trepel JB, Thomas A. Takahashi N, et al. Among authors: kumar s. Cold Spring Harb Mol Case Stud. 2020 Oct 7;6(5):a005678. doi: 10.1101/mcs.a005678. Print 2020 Oct. Cold Spring Harb Mol Case Stud. 2020. PMID: 33028646 Free PMC article.
Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer.
Roper N, Velez MJ, Chiappori A, Kim YS, Wei JS, Sindiri S, Takahashi N, Mulford D, Kumar S, Ylaya K, Trindade C, Manukyan I, Brown AL, Trepel JB, Lee JM, Hewitt S, Khan J, Thomas A. Roper N, et al. Among authors: kumar s. Nat Commun. 2021 Jun 23;12(1):3880. doi: 10.1038/s41467-021-24164-y. Nat Commun. 2021. PMID: 34162872 Free PMC article.
Replication stress defines distinct molecular subtypes across cancers.
Takahashi N, Kim S, Schultz CW, Rajapakse VN, Zhang Y, Redon CE, Fu H, Pongor L, Kumar S, Pommier Y, Aladjem MI, Thomas A. Takahashi N, et al. Among authors: kumar s. Cancer Res Commun. 2022 Jun;2(6):503-517. doi: 10.1158/2767-9764.crc-22-0168. Epub 2022 Jun 24. Cancer Res Commun. 2022. PMID: 36381660 Free PMC article.
Preclinical Models of Neuroendocrine Neoplasia.
Sedlack AJH, Saleh-Anaraki K, Kumar S, Ear PH, Lines KE, Roper N, Pacak K, Bergsland E, Quelle DE, Howe JR, Pommier Y, Del Rivero J. Sedlack AJH, et al. Among authors: kumar s. Cancers (Basel). 2022 Nov 17;14(22):5646. doi: 10.3390/cancers14225646. Cancers (Basel). 2022. PMID: 36428741 Free PMC article. Review.
Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and Is Associated with Worse Outcomes.
Pongor LS, Schultz CW, Rinaldi L, Wangsa D, Redon CE, Takahashi N, Fialkoff G, Desai P, Zhang Y, Burkett S, Hermoni N, Vilk N, Gutin J, Gergely R, Zhao Y, Nichols S, Vilimas R, Sciuto L, Graham C, Caravaca JM, Turan S, Tsai-Wei S, Rajapakse VN, Kumar R, Upadhyay D, Kumar S, Kim YS, Roper N, Tran B, Hewitt SM, Kleiner DE, Aladjem MI, Friedman N, Hager GL, Pommier Y, Ried T, Thomas A. Pongor LS, et al. Among authors: kumar s, kumar r. Cancer Discov. 2023 Apr 3;13(4):928-949. doi: 10.1158/2159-8290.CD-22-0796. Cancer Discov. 2023. PMID: 36715552 Free PMC article.
Preclinical Models of Adrenocortical Cancer.
Sedlack AJH, Hatfield SJ, Kumar S, Arakawa Y, Roper N, Sun NY, Nilubol N, Kiseljak-Vassiliades K, Hoang CD, Bergsland EK, Hernandez JM, Pommier Y, Del Rivero J. Sedlack AJH, et al. Among authors: kumar s. Cancers (Basel). 2023 May 23;15(11):2873. doi: 10.3390/cancers15112873. Cancers (Basel). 2023. PMID: 37296836 Free PMC article. Review.
Targeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex.
Sun Y, Baechler SA, Zhang X, Kumar S, Factor VM, Arakawa Y, Chau CH, Okamoto K, Parikh A, Walker B, Su YP, Chen J, Ting T, Huang SN, Beck E, Itkin Z, McKnight C, Xie C, Roper N, Nijhawan D, Figg WD, Meltzer PS, Yang JC, Thomas CJ, Pommier Y. Sun Y, et al. Among authors: kumar s. Nat Commun. 2023 Jun 23;14(1):3762. doi: 10.1038/s41467-023-39374-9. Nat Commun. 2023. PMID: 37353483 Free PMC article.
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