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PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8+ T-cell Function.
Whelan S, Ophir E, Kotturi MF, Levy O, Ganguly S, Leung L, Vaknin I, Kumar S, Dassa L, Hansen K, Bernados D, Murter B, Soni A, Taube JM, Fader AN, Wang TL, Shih IM, White M, Pardoll DM, Liang SC. Whelan S, et al. Among authors: kumar s. Cancer Immunol Res. 2019 Feb;7(2):257-268. doi: 10.1158/2326-6066.CIR-18-0442. Epub 2019 Jan 18. Cancer Immunol Res. 2019. PMID: 30659054 Free PMC article.
COM902, a novel therapeutic antibody targeting TIGIT augments anti-tumor T cell function in combination with PVRIG or PD-1 pathway blockade.
Hansen K, Kumar S, Logronio K, Whelan S, Qurashi S, Cheng HY, Drake A, Tang M, Wall P, Bernados D, Leung L, Ophir E, Alteber Z, Cojocaru G, Galperin M, Frenkel M, White M, Hunter J, Liang SC, Kotturi MF. Hansen K, et al. Among authors: kumar s. Cancer Immunol Immunother. 2021 Dec;70(12):3525-3540. doi: 10.1007/s00262-021-02921-8. Epub 2021 Apr 26. Cancer Immunol Immunother. 2021. PMID: 33903974 Free PMC article.
Antibody-mediated targeting of TNFR2 activates CD8+ T cells in mice and promotes antitumor immunity.
Tam EM, Fulton RB, Sampson JF, Muda M, Camblin A, Richards J, Koshkaryev A, Tang J, Kurella V, Jiao Y, Xu L, Zhang K, Kohli N, Luus L, Hutto E, Kumar S, Lulo J, Paragas V, Wong C, Suchy J, Grabow S, Dugast AS, Zhang H, Depis F, Feau S, Jakubowski A, Qiao W, Craig G, Razlog M, Qiu J, Zhou Y, Marks JD, Croft M, Drummond DC, Raue A. Tam EM, et al. Among authors: kumar s. Sci Transl Med. 2019 Oct 2;11(512):eaax0720. doi: 10.1126/scitranslmed.aax0720. Sci Transl Med. 2019. PMID: 31578241
Mitochondrial dysfunction-mediated apoptosis resistance associates with defective heat shock protein response in African-American men with prostate cancer.
Chaudhary AK, Bhat TA, Kumar S, Kumar A, Kumar R, Underwood W, Koochekpour S, Shourideh M, Yadav N, Dhar S, Chandra D. Chaudhary AK, et al. Among authors: kumar s, kumar r, kumar a. Br J Cancer. 2016 May 10;114(10):1090-100. doi: 10.1038/bjc.2016.88. Epub 2016 Apr 26. Br J Cancer. 2016. PMID: 27115471 Free PMC article.
Hsp60 and IL-8 axis promotes apoptosis resistance in cancer.
Kumar S, O'Malley J, Chaudhary AK, Inigo JR, Yadav N, Kumar R, Chandra D. Kumar S, et al. Among authors: kumar r. Br J Cancer. 2019 Nov;121(11):934-943. doi: 10.1038/s41416-019-0617-0. Epub 2019 Nov 1. Br J Cancer. 2019. PMID: 31673102 Free PMC article.
Targeting Cytokines in GVHD Therapy.
Kumar S, Mohammadpour H, Cao X. Kumar S, et al. J Immunol Res Ther. 2017;2(1):90-99. Epub 2017 Jun 28. J Immunol Res Ther. 2017. PMID: 28819653 Free PMC article.
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