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Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models.
Iyaswamy A, Wang X, Krishnamoorthi S, Kaliamoorthy V, Sreenivasmurthy SG, Kumar Durairajan SS, Song JX, Tong BC, Zhu Z, Su CF, Liu J, Cheung KH, Lu JH, Tan JQ, Li HW, Wong MS, Li M. Iyaswamy A, et al. Among authors: kumar durairajan ss. Redox Biol. 2022 May;51:102280. doi: 10.1016/j.redox.2022.102280. Epub 2022 Mar 8. Redox Biol. 2022. PMID: 35286997 Free PMC article.
Chronic oral administration of adipoRon reverses cognitive impairments and ameliorates neuropathology in an Alzheimer's disease mouse model.
Ng RC, Jian M, Ma OK, Bunting M, Kwan JS, Zhou GJ, Senthilkumar K, Iyaswamy A, Chan PK, Li M, Leung KM, Kumar Durairajan SS, Lam KS, Chu LW, Festenstein R, Chung SK, Chan KH. Ng RC, et al. Among authors: kumar durairajan ss. Mol Psychiatry. 2021 Oct;26(10):5669-5689. doi: 10.1038/s41380-020-0701-0. Epub 2020 Mar 4. Mol Psychiatry. 2021. PMID: 32132650
Bromo-protopine, a novel protopine derivative, alleviates tau pathology by activating chaperone-mediated autophagy for Alzheimer's disease therapy.
Sreenivasmurthy SG, Iyaswamy A, Krishnamoorthi S, Reddi RN, Kammala AK, Vasudevan K, Senapati S, Zhu Z, Su CF, Liu J, Guan XJ, Chua KK, Cheung KH, Chen H, Zhang HJ, Zhang Y, Song JX, Kumar Durairajan SS, Li M. Sreenivasmurthy SG, et al. Among authors: kumar durairajan ss. Front Mol Biosci. 2022 Oct 26;9:1030534. doi: 10.3389/fmolb.2022.1030534. eCollection 2022. Front Mol Biosci. 2022. PMID: 36387280 Free PMC article.