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Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes.
Gunasekar SK, Xie L, Kumar A, Hong J, Chheda PR, Kang C, Kern DM, My-Ta C, Maurer J, Heebink J, Gerber EE, Grzesik WJ, Elliot-Hudson M, Zhang Y, Key P, Kulkarni CA, Beals JW, Smith GI, Samuel I, Smith JK, Nau P, Imai Y, Sheldon RD, Taylor EB, Lerner DJ, Norris AW, Klein S, Brohawn SG, Kerns R, Sah R. Gunasekar SK, et al. Among authors: kumar a. Nat Commun. 2022 Feb 10;13(1):784. doi: 10.1038/s41467-022-28435-0. Nat Commun. 2022. PMID: 35145074 Free PMC article.
SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism.
Kumar A, Xie L, Ta CM, Hinton AO, Gunasekar SK, Minerath RA, Shen K, Maurer JM, Grueter CE, Abel ED, Meyer G, Sah R. Kumar A, et al. Elife. 2020 Sep 15;9:e58941. doi: 10.7554/eLife.58941. Elife. 2020. PMID: 32930093 Free PMC article.
These proteins are studded through the cell membranes, where they can respond to mechanical changes by opening and allowing the flow of ions in and out of a cell, or by changing interactions with other proteins. The SWELL1 protein is a component of an ion channel kn …
These proteins are studded through the cell membranes, where they can respond to mechanical changes by opening and allowing the flow of ions …
The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function.
Alghanem AF, Abello J, Maurer JM, Kumar A, Ta CM, Gunasekar SK, Fatima U, Kang C, Xie L, Adeola O, Riker M, Elliot-Hudson M, Minerath RA, Grueter CE, Mullins RF, Stratman AN, Sah R. Alghanem AF, et al. Among authors: kumar a. Elife. 2021 Feb 25;10:e61313. doi: 10.7554/eLife.61313. Elife. 2021. PMID: 33629656 Free PMC article.
Mechanosensing in Metabolism.
Tranter JD, Kumar A, Nair VK, Sah R. Tranter JD, et al. Among authors: kumar a. Compr Physiol. 2023 Dec 29;14(1):5269-5290. doi: 10.1002/cphy.c230005. Compr Physiol. 2023. PMID: 38158369 Review.
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