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A methionine-Mettl3-N6-methyladenosine axis promotes polycystic kidney disease.
Ramalingam H, Kashyap S, Cobo-Stark P, Flaten A, Chang CM, Hajarnis S, Hein KZ, Lika J, Warner GM, Espindola-Netto JM, Kumar A, Kanchwala M, Xing C, Chini EN, Patel V. Ramalingam H, et al. Among authors: kumar a. Cell Metab. 2021 Jun 1;33(6):1234-1247.e7. doi: 10.1016/j.cmet.2021.03.024. Epub 2021 Apr 13. Cell Metab. 2021. PMID: 33852874 Free PMC article.
Forward genetic analysis using OCT screening identifies Sfxn3 mutations leading to progressive outer retinal degeneration in mice.
Chen B, Aredo B, Ding Y, Zhong X, Zhu Y, Zhao CX, Kumar A, Xing C, Gautron L, Lyon S, Russell J, Li X, Tang M, Anderton P, Ludwig S, Moresco EMY, Beutler B, Ufret-Vincenty RL. Chen B, et al. Among authors: kumar a. Proc Natl Acad Sci U S A. 2020 Jun 9;117(23):12931-12942. doi: 10.1073/pnas.1921224117. Epub 2020 May 26. Proc Natl Acad Sci U S A. 2020. PMID: 32457148 Free PMC article.
SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A.
Scarborough AM, Flaherty JN, Hunter OV, Liu K, Kumar A, Xing C, Tu BP, Conrad NK. Scarborough AM, et al. Among authors: kumar a. Elife. 2021 May 5;10:e64930. doi: 10.7554/eLife.64930. Elife. 2021. PMID: 33949310 Free PMC article.
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