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Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus.
McLellan JS, Chen M, Joyce MG, Sastry M, Stewart-Jones GB, Yang Y, Zhang B, Chen L, Srivatsan S, Zheng A, Zhou T, Graepel KW, Kumar A, Moin S, Boyington JC, Chuang GY, Soto C, Baxa U, Bakker AQ, Spits H, Beaumont T, Zheng Z, Xia N, Ko SY, Todd JP, Rao S, Graham BS, Kwong PD. McLellan JS, et al. Among authors: kumar a. Science. 2013 Nov 1;342(6158):592-8. doi: 10.1126/science.1243283. Science. 2013. PMID: 24179220 Free PMC article.
Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein.
Gilman MS, Moin SM, Mas V, Chen M, Patel NK, Kramer K, Zhu Q, Kabeche SC, Kumar A, Palomo C, Beaumont T, Baxa U, Ulbrandt ND, Melero JA, Graham BS, McLellan JS. Gilman MS, et al. Among authors: kumar a. PLoS Pathog. 2015 Jul 10;11(7):e1005035. doi: 10.1371/journal.ppat.1005035. eCollection 2015 Jul. PLoS Pathog. 2015. PMID: 26161532 Free PMC article.
Prefusion F-specific antibodies determine the magnitude of RSV neutralizing activity in human sera.
Ngwuta JO, Chen M, Modjarrad K, Joyce MG, Kanekiyo M, Kumar A, Yassine HM, Moin SM, Killikelly AM, Chuang GY, Druz A, Georgiev IS, Rundlet EJ, Sastry M, Stewart-Jones GB, Yang Y, Zhang B, Nason MC, Capella C, Peeples ME, Ledgerwood JE, McLellan JS, Kwong PD, Graham BS. Ngwuta JO, et al. Among authors: kumar a. Sci Transl Med. 2015 Oct 14;7(309):309ra162. doi: 10.1126/scitranslmed.aac4241. Sci Transl Med. 2015. PMID: 26468324 Free PMC article.
Packaging and Prefusion Stabilization Separately and Additively Increase the Quantity and Quality of Respiratory Syncytial Virus (RSV)-Neutralizing Antibodies Induced by an RSV Fusion Protein Expressed by a Parainfluenza Virus Vector.
Liang B, Ngwuta JO, Herbert R, Swerczek J, Dorward DW, Amaro-Carambot E, Mackow N, Kabatova B, Lingemann M, Surman S, Yang L, Chen M, Moin SM, Kumar A, McLellan JS, Kwong PD, Graham BS, Schaap-Nutt A, Collins PL, Munir S. Liang B, et al. Among authors: kumar a. J Virol. 2016 Oct 14;90(21):10022-10038. doi: 10.1128/JVI.01196-16. Print 2016 Nov 1. J Virol. 2016. PMID: 27581977 Free PMC article.
Improved Prefusion Stability, Optimized Codon Usage, and Augmented Virion Packaging Enhance the Immunogenicity of Respiratory Syncytial Virus Fusion Protein in a Vectored-Vaccine Candidate.
Liang B, Ngwuta JO, Surman S, Kabatova B, Liu X, Lingemann M, Liu X, Yang L, Herbert R, Swerczek J, Chen M, Moin SM, Kumar A, McLellan JS, Kwong PD, Graham BS, Collins PL, Munir S. Liang B, et al. Among authors: kumar a. J Virol. 2017 Jul 12;91(15):e00189-17. doi: 10.1128/JVI.00189-17. Print 2017 Aug 1. J Virol. 2017. PMID: 28539444 Free PMC article.
Adjuvants and the vaccine response to the DS-Cav1-stabilized fusion glycoprotein of respiratory syncytial virus.
Sastry M, Zhang B, Chen M, Joyce MG, Kong WP, Chuang GY, Ko K, Kumar A, Silacci C, Thom M, Salazar AM, Corti D, Lanzavecchia A, Taylor G, Mascola JR, Graham BS, Kwong PD. Sastry M, et al. Among authors: kumar a. PLoS One. 2017 Oct 26;12(10):e0186854. doi: 10.1371/journal.pone.0186854. eCollection 2017. PLoS One. 2017. PMID: 29073183 Free PMC article.
Breast Milk Prefusion F Immunoglobulin G as a Correlate of Protection Against Respiratory Syncytial Virus Acute Respiratory Illness.
Mazur NI, Horsley NM, Englund JA, Nederend M, Magaret A, Kumar A, Jacobino SR, de Haan CAM, Khatry SK, LeClerq SC, Steinhoff MC, Tielsch JM, Katz J, Graham BS, Bont LJ, Leusen JHW, Chu HY. Mazur NI, et al. Among authors: kumar a. J Infect Dis. 2019 Jan 1;219(1):59-67. doi: 10.1093/infdis/jiy477. J Infect Dis. 2019. PMID: 30107412 Free PMC article.
Epitope-Specific Serological Assays for RSV: Conformation Matters.
Phung E, Chang LA, Morabito KM, Kanekiyo M, Chen M, Nair D, Kumar A, Chen GL, Ledgerwood JE, Graham BS, Ruckwardt TJ. Phung E, et al. Among authors: kumar a. Vaccines (Basel). 2019 Feb 23;7(1):23. doi: 10.3390/vaccines7010023. Vaccines (Basel). 2019. PMID: 30813394 Free PMC article.
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