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Dual PI3Kδγ inhibition demonstrates potent anticancer effects in diffuse large B-cell lymphoma models: Discovery and preclinical characterization of LL-00084282.
Verma MK, Samant C, Kale R, Patra S, Mahajan N, Gholve MK, Marisetti A, Sunkara B, Naik A, Shingare M, Reddy M, Bokare AM, Akarte A, Koul S, Nigade PB, Patil VB, Modi D, Ahirrao P, Pawar S, Kuldharan S, Dinchhana L, Mehta M, Gundu J, Jana N, Vidhate P, Mahangare SJ, Shukla MR, Goel RN, Bhonde M, Kamboj RK, Palle VP. Verma MK, et al. Among authors: kuldharan s. Biochem Biophys Res Commun. 2022 Dec 31;637:267-275. doi: 10.1016/j.bbrc.2022.11.038. Epub 2022 Nov 15. Biochem Biophys Res Commun. 2022. PMID: 36410276
Discovery and pre-clinical characterization of a selective PI3Kδ inhibitor, LL-00071210 in rheumatoid arthritis.
Kanoje V, Pandey D, Wagh A, Patra S, Kumar Marisetti A, Reddy M, Samant C, Mahajan N, Gholve M, Sabde S, Trivedi S, Bhankhede T, Patil V, Nigade P, Modi D, Mehta M, Ahirrao P, Tota S, Nanda B, Pawar S, Polawar A, Tamane K, Kuldharan S, Vishwase G, Jana N, Mahangare SJ, Vidhate P, Lagad D, Gundu J, Phukan S, Shukla M, Narasimham L, Nemmani KVS, Bhonde M, Sharma S, Kamboj RK, Palle VP. Kanoje V, et al. Among authors: kuldharan s. Eur J Pharmacol. 2022 Jul 15;927:175054. doi: 10.1016/j.ejphar.2022.175054. Epub 2022 May 27. Eur J Pharmacol. 2022. PMID: 35636524
Discovery of a Novel Potent and Selective Calcium Release-Activated Calcium Channel Inhibitor: 2,6-Difluoro-N-(2'-methyl-3'-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-[1,1'-biphenyl]-4-yl)benzamide. Structure-Activity Relationship and Preclinical Characterization.
Khedkar NR, Irlapatti NR, Dadke D, Kanoje V, Shaikh Z, Karche V, Shinde V, Deshmukh G, Patil A, Jachak S, Phukan S, Kizhakinagath PA, Gholve M, Bhankhede T, Daler J, Nemade HN, Budhe S, Pareek H, Yeshodharan R, Gupta R, Kalia A, Pandey D, Wagh A, Kumar S, Patil V, Modi D, Sharma N, Ahirrao P, Mehta M, Kumar H, Nigade P, Tamane K, Mallurwar S, Kuldharan S, Pawar S, Vishwase G, Bokan S, Singh M, Naik K, Ingawale S, Shankar R, Kamalakannan P, Venugopal S, George SK, Padiya KJ, Nemmani KVS, Gundu J, Bhonde M, Narasimham L, Sindkhedkar M, Shah C, Sinha N, Sharma S, Bakhle D, Kamboj RK, Palle VP. Khedkar NR, et al. Among authors: kuldharan s. J Med Chem. 2021 Dec 9;64(23):17004-17030. doi: 10.1021/acs.jmedchem.1c01403. Epub 2021 Nov 29. J Med Chem. 2021. PMID: 34843241
Discovery and Characterization of Potent Pan-Genotypic HCV NS5A Inhibitors Containing Novel Tricyclic Central Core Leading to Clinical Candidate.
Ramdas V, Talwar R, Banerjee M, Joshi AA, Das AK, Walke DS, Borhade P, Dhayagude U, Loriya R, Gote G, Bommakanti A, Sivaram A, Agarwal G, Goswami A, Nigade P, Mehta M, Patil V, Modi D, Kumar H, Mallurwar S, Dash A, Modi F, Kuldharan S, Srivastava P, Singh M, Narasimham L, Gundu J, Sharma S, Kamboj RK, Palle VP. Ramdas V, et al. Among authors: kuldharan s. J Med Chem. 2019 Dec 12;62(23):10563-10582. doi: 10.1021/acs.jmedchem.9b01562. Epub 2019 Nov 22. J Med Chem. 2019. PMID: 31710479
In vitro and in vivo activities of antibiotic PM181104.
Mahajan G, Thomas B, Parab R, Patel ZE, Kuldharan S, Yemparala V, Mishra PD, Ranadive P, D'Souza L, Pari K, Sivaramkrishnan H. Mahajan G, et al. Among authors: kuldharan s. Antimicrob Agents Chemother. 2013 Nov;57(11):5315-9. doi: 10.1128/AAC.01059-13. Epub 2013 Aug 12. Antimicrob Agents Chemother. 2013. PMID: 23939903 Free PMC article.