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Deficiency of stress-associated gene Nupr1 increases bone volume by attenuating differentiation of osteoclasts and enhancing differentiation of osteoblasts.
Shiraki M, Xu X, Iovanna JL, Kukita T, Hirata H, Kamohara A, Kubota Y, Miyamoto H, Mawatari M, Kukita A. Shiraki M, et al. Among authors: kukita t, kukita a. FASEB J. 2019 Aug;33(8):8836-8852. doi: 10.1096/fj.201802322RR. Epub 2019 May 8. FASEB J. 2019. PMID: 31067083
Nuclear protein 1 (NUPR1) is a multifunctional stress-induced protein involved in regulating tumorigenesis, apoptosis, and autophagy. ...Collectively, these results indicate that Nupr1 deficiency increases bone volume by attenuating production of Sost and osteoclastogenesi …
Nuclear protein 1 (NUPR1) is a multifunctional stress-induced protein involved in regulating tumorigenesis, apoptosis, and autophagy. …
Leukemia/lymphoma-related factor (LRF) or osteoclast zinc finger protein (OCZF) overexpression promotes osteoclast survival by increasing Bcl-xl mRNA: A novel regulatory mechanism mediated by the RNA binding protein SAM68.
Xu X, Shobuike T, Shiraki M, Kamohara A, Hirata H, Murayama M, Mawatari D, Ueno M, Morimoto T, Kukita T, Mawatari M, Kukita A. Xu X, et al. Among authors: kukita a. Lab Invest. 2022 Sep;102(9):1000-1010. doi: 10.1038/s41374-022-00792-w. Epub 2022 Apr 26. Lab Invest. 2022. PMID: 35474350 Free article.
Prostate transmembrane protein androgen induced 1 is induced by activation of osteoclasts and regulates bone resorption.
Xu X, Hirata H, Shiraki M, Kamohara A, Nishioka K, Miyamoto H, Kukita T, Kukita A. Xu X, et al. Among authors: kukita t, kukita a. FASEB J. 2019 Mar;33(3):4365-4375. doi: 10.1096/fj.201801573R. Epub 2018 Dec 17. FASEB J. 2019. PMID: 30557043
Our results suggest that Pmepa1 is a critical regulator of bone resorption and is a promising marker for activated osteoclasts and a potential therapeutic target in pathologic bone destruction.-Xu, X., Hirata, H., Shiraki, M., Kamohara, A., Nishioka, K …
Our results suggest that Pmepa1 is a critical regulator of bone resorption and is a promising marker for activated osteoclasts …
213 results