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Report of the First ONTOX Stakeholder Network Meeting: Digging Under the Surface of ONTOX Together With the Stakeholders.
Diemar MG, Vinken M, Teunis M, Krul CAM, Busquet F, Zajac JD, Kandarova H, Corvi R, Rosso MZ, Kharina A, Bryndum LS, Santillo M, Bloch D, Kucheryavenko O, Panagiotakos D, Rogiers V, Beekhuijzen M, Giusti A, Najjar A, Courage C, Koenig T, Kolle S, Boonen H, Dhalluin S, Boberg J, Müller BP, Kukic P, Ritskes-Hoitinga M, Grasselli E, Zietek T, Stoddart G, Heusinkveld HJ, Castell JV, Benfenati E, Yang H, Perera S, Paini A, Kramer NI, Hartung T, Janssen M, Fritsche E, Jennen DGJ, Piumatti M, Rathman J, Marusczyk J, Milec L, Roggen EL. Diemar MG, et al. Among authors: kukic p. Altern Lab Anim. 2024 Mar;52(2):117-131. doi: 10.1177/02611929231225730. Epub 2024 Jan 18. Altern Lab Anim. 2024. PMID: 38235727 Free article.
Using transcriptomics, proteomics and phosphoproteomics as new approach methodology (NAM) to define biological responses for chemical safety assessment.
Li Y, Zhang Z, Jiang S, Xu F, Tulum L, Li K, Liu S, Li S, Chang L, Liddell M, Tu F, Gu X, Carmichael PL, White A, Peng S, Zhang Q, Li J, Zuo T, Kukic P, Xu P. Li Y, et al. Among authors: kukic p. Chemosphere. 2023 Feb;313:137359. doi: 10.1016/j.chemosphere.2022.137359. Epub 2022 Nov 22. Chemosphere. 2023. PMID: 36427571
The phosphoproteome is a first responder in tiered cellular adaptation to chemical stress followed by proteomics and transcriptomics alteration.
Chen P, Li Y, Long Q, Zuo T, Zhang Z, Guo J, Xu D, Li K, Liu S, Li S, Yin J, Chang L, Kukic P, Liddell M, Tulum L, Carmichael P, Peng S, Li J, Zhang Q, Xu P. Chen P, et al. Among authors: kukic p. Chemosphere. 2023 Dec;344:140329. doi: 10.1016/j.chemosphere.2023.140329. Epub 2023 Sep 30. Chemosphere. 2023. PMID: 37783352
Are Non-animal Systemic Safety Assessments Protective? A Toolbox and Workflow.
Middleton AM, Reynolds J, Cable S, Baltazar MT, Li H, Bevan S, Carmichael PL, Dent MP, Hatherell S, Houghton J, Kukic P, Liddell M, Malcomber S, Nicol B, Park B, Patel H, Scott S, Sparham C, Walker P, White A. Middleton AM, et al. Among authors: kukic p. Toxicol Sci. 2022 Aug 25;189(1):124-147. doi: 10.1093/toxsci/kfac068. Toxicol Sci. 2022. PMID: 35822611 Free PMC article.
Beyond AOPs: A Mechanistic Evaluation of NAMs in DART Testing.
Rajagopal R, Baltazar MT, Carmichael PL, Dent MP, Head J, Li H, Muller I, Reynolds J, Sadh K, Simpson W, Spriggs S, White A, Kukic P. Rajagopal R, et al. Among authors: kukic p. Front Toxicol. 2022 Mar 7;4:838466. doi: 10.3389/ftox.2022.838466. eCollection 2022. Front Toxicol. 2022. PMID: 35295212 Free PMC article.
Confidence in Inactive and Active Predictions from Structural Alerts.
Wedlake AJ, Allen TEH, Goodman JM, Gutsell S, Kukic P, Russell PJ. Wedlake AJ, et al. Among authors: kukic p. Chem Res Toxicol. 2020 Dec 21;33(12):3010-3022. doi: 10.1021/acs.chemrestox.0c00332. Epub 2020 Dec 9. Chem Res Toxicol. 2020. PMID: 33295767
A Next-Generation Risk Assessment Case Study for Coumarin in Cosmetic Products.
Baltazar MT, Cable S, Carmichael PL, Cubberley R, Cull T, Delagrange M, Dent MP, Hatherell S, Houghton J, Kukic P, Li H, Lee MY, Malcomber S, Middleton AM, Moxon TE, Nathanail AV, Nicol B, Pendlington R, Reynolds G, Reynolds J, White A, Westmoreland C. Baltazar MT, et al. Among authors: kukic p. Toxicol Sci. 2020 Jul 1;176(1):236-252. doi: 10.1093/toxsci/kfaa048. Toxicol Sci. 2020. PMID: 32275751 Free PMC article.
28 results