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Spns1 is a lysophospholipid transporter mediating lysosomal phospholipid salvage.
Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2210353119. doi: 10.1073/pnas.2210353119. Epub 2022 Sep 26.
Proc Natl Acad Sci U S A. 2022.
PMID: 36161949
Free PMC article.
Biallelic MFSD2A variants associated with congenital microcephaly, developmental delay, and recognizable neuroimaging features.
Scala M, Chua GL, Chin CF, Alsaif HS, Borovikov A, Riazuddin S, Riazuddin S, Chiara Manzini M, Severino M, Kuk A, Fan H, Jamshidi Y, Toosi MB, Doosti M, Karimiani EG, Salpietro V, Dadali E, Baydakova G, Konovalov F, Lozier E, O'Connor E, Sabr Y, Alfaifi A, Ashrafzadeh F, Striano P, Zara F, Alkuraya FS, Houlden H, Maroofian R, Silver DL.
Scala M, et al.
Eur J Hum Genet. 2020 Nov;28(11):1509-1519. doi: 10.1038/s41431-020-0669-x. Epub 2020 Jun 22.
Eur J Hum Genet. 2020.
PMID: 32572202
Free PMC article.
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Mfsd2a utilizes a flippase mechanism to mediate omega-3 fatty acid lysolipid transport.
Chua GL, Tan BC, Loke RYJ, He M, Chin CF, Wong BH, Kuk ACY, Ding M, Wenk MR, Guan L, Torta F, Silver DL.
Chua GL, et al. Among authors: kuk acy.
Proc Natl Acad Sci U S A. 2023 Mar 7;120(10):e2215290120. doi: 10.1073/pnas.2215290120. Epub 2023 Feb 27.
Proc Natl Acad Sci U S A. 2023.
PMID: 36848557
Free PMC article.
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The cellular supply-side economics for phospholipids.
Kuk ACY, Silver DL.
Kuk ACY, et al.
Cell Metab. 2023 Jun 6;35(6):909-911. doi: 10.1016/j.cmet.2023.05.004.
Cell Metab. 2023.
PMID: 37285806
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Structure and Mechanism of the Lipid Flippase MurJ.
Kuk ACY, Hao A, Lee SY.
Kuk ACY, et al.
Annu Rev Biochem. 2022 Jun 21;91:705-729. doi: 10.1146/annurev-biochem-040320-105145. Epub 2022 Mar 23.
Annu Rev Biochem. 2022.
PMID: 35320686
Free PMC article.
Review.
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Crystal structure of the MOP flippase MurJ in an inward-facing conformation.
Kuk AC, Mashalidis EH, Lee SY.
Kuk AC, et al.
Nat Struct Mol Biol. 2017 Feb;24(2):171-176. doi: 10.1038/nsmb.3346. Epub 2016 Dec 26.
Nat Struct Mol Biol. 2017.
PMID: 28024149
Free PMC article.
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GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation.
Yoo J, Mashalidis EH, Kuk ACY, Yamamoto K, Kaeser B, Ichikawa S, Lee SY.
Yoo J, et al. Among authors: kuk acy.
Nat Struct Mol Biol. 2018 Mar;25(3):217-224. doi: 10.1038/s41594-018-0031-y. Epub 2018 Feb 19.
Nat Struct Mol Biol. 2018.
PMID: 29459785
Free PMC article.
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Visualizing conformation transitions of the Lipid II flippase MurJ.
Kuk ACY, Hao A, Guan Z, Lee SY.
Kuk ACY, et al.
Nat Commun. 2019 Apr 15;10(1):1736. doi: 10.1038/s41467-019-09658-0.
Nat Commun. 2019.
PMID: 30988294
Free PMC article.
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