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Signal peptide mimicry primes Sec61 for client-selective inhibition.
Rehan S, Tranter D, Sharp PP, Craven GB, Lowe E, Anderl JL, Muchamuel T, Abrishami V, Kuivanen S, Wenzell NA, Jennings A, Kalyanaraman C, Strandin T, Javanainen M, Vapalahti O, Jacobson MP, McMinn D, Kirk CJ, Huiskonen JT, Taunton J, Paavilainen VO. Rehan S, et al. Among authors: kuivanen s. Nat Chem Biol. 2023 Sep;19(9):1054-1062. doi: 10.1038/s41589-023-01326-1. Epub 2023 May 11. Nat Chem Biol. 2023. PMID: 37169961 Free PMC article.
Intranasal trimeric sherpabody inhibits SARS-CoV-2 including recent immunoevasive Omicron subvariants.
Mäkelä AR, Uğurlu H, Hannula L, Kant R, Salminen P, Fagerlund R, Mäki S, Haveri A, Strandin T, Kareinen L, Hepojoki J, Kuivanen S, Levanov L, Pasternack A, Naves RA, Ritvos O, Österlund P, Sironen T, Vapalahti O, Kipar A, Huiskonen JT, Rissanen I, Saksela K. Mäkelä AR, et al. Among authors: kuivanen s. Nat Commun. 2023 Mar 24;14(1):1637. doi: 10.1038/s41467-023-37290-6. Nat Commun. 2023. PMID: 36964125 Free PMC article.
Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein.
Yang K, Wang C, Kreutzberger AJB, Ojha R, Kuivanen S, Couoh-Cardel S, Muratcioglu S, Eisen TJ, White KI, Held RG, Subramanian S, Marcus K, Pfuetzner RA, Esquivies L, Doyle CA, Kuriyan J, Vapalahti O, Balistreri G, Kirchhausen T, Brunger AT. Yang K, et al. Among authors: kuivanen s. Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2210990119. doi: 10.1073/pnas.2210990119. Epub 2022 Sep 19. Proc Natl Acad Sci U S A. 2022. PMID: 36122200 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 36783625
Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models.
Freitag TL, Fagerlund R, Karam NL, Leppänen VM, Ugurlu H, Kant R, Mäkinen P, Tawfek A, Jha SK, Strandin T, Leskinen K, Hepojoki J, Kesti T, Kareinen L, Kuivanen S, Koivulehto E, Sormunen A, Laidinen S, Khattab A, Saavalainen P, Meri S, Kipar A, Sironen T, Vapalahti O, Alitalo K, Ylä-Herttuala S, Saksela K. Freitag TL, et al. Among authors: kuivanen s. Vaccine. 2023 May 11;41(20):3233-3246. doi: 10.1016/j.vaccine.2023.04.020. Epub 2023 Apr 14. Vaccine. 2023. PMID: 37085458 Free PMC article.
43 results