Kuhn PH - Search Results

1

A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases.

Bernhardt AM, Tiedt S, Teupser D, Dichgans M, Meyer B, Gempt J, Kuhn PH, Simons M, Palleis C, Weidinger E, Nübling G, Holdt L, Hönikl L, Gasperi C, Giesbertz P, Müller SA, Breimann S, Lichtenthaler SF, Kuster B, Mann M, Imhof A, Barth T, Hauck SM, Zetterberg H, Otto M, Weichert W, Hemmer B, Levin J. Bernhardt AM, et al. Among authors: kuhn ph. EBioMedicine. 2023 Mar;89:104456. doi: 10.1016/j.ebiom.2023.104456. Epub 2023 Feb 4. EBioMedicine. 2023. PMID: 36745974 Free PMC article. Review.

2

Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase.

Hogl S, Kuhn PH, Colombo A, Lichtenthaler SF. Hogl S, et al. Among authors: kuhn ph. PLoS One. 2011;6(6):e21337. doi: 10.1371/journal.pone.0021337. Epub 2011 Jun 17. PLoS One. 2011. PMID: 21695060 Free PMC article.

3

Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo.

Dislich B, Wohlrab F, Bachhuber T, Müller SA, Kuhn PH, Hogl S, Meyer-Luehmann M, Lichtenthaler SF. Dislich B, et al. Among authors: kuhn ph. Mol Cell Proteomics. 2015 Oct;14(10):2550-63. doi: 10.1074/mcp.M114.041533. Epub 2015 Jul 2. Mol Cell Proteomics. 2015. PMID: 26139848 Free PMC article.

4

An optimised version of the secretome protein enrichment with click sugars (SPECS) method leads to enhanced coverage of the secretome.

Serdaroglu A, Müller SA, Schepers U, Bräse S, Weichert W, Lichtenthaler SF, Kuhn PH. Serdaroglu A, et al. Among authors: kuhn ph. Proteomics. 2017 Mar;17(5). doi: 10.1002/pmic.201600423. Epub 2017 Jan 31. Proteomics. 2017. PMID: 27991726

5

Evaluation of Disposable Trap Column nanoLC-FAIMS-MS/MS for the Proteomic Analysis of FFPE Tissue.

Eckert S, Chang YC, Bayer FP, The M, Kuhn PH, Weichert W, Kuster B. Eckert S, et al. Among authors: kuhn ph. J Proteome Res. 2021 Dec 3;20(12):5402-5411. doi: 10.1021/acs.jproteome.1c00695. Epub 2021 Nov 4. J Proteome Res. 2021. PMID: 34735149 Free PMC article.

6

Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.

Pigoni M, Wanngren J, Kuhn PH, Munro KM, Gunnersen JM, Takeshima H, Feederle R, Voytyuk I, De Strooper B, Levasseur MD, Hrupka BJ, Müller SA, Lichtenthaler SF. Pigoni M, et al. Among authors: kuhn ph. Mol Neurodegener. 2016 Oct 5;11(1):67. doi: 10.1186/s13024-016-0134-z. Mol Neurodegener. 2016. PMID: 27716410 Free PMC article.

7

Cell Type-Specific Human APP Transgene Expression by Hippocampal Interneurons in the Tg2576 Mouse Model of Alzheimer's Disease.

Höfling C, Shehabi E, Kuhn PH, Lichtenthaler SF, Hartlage-Rübsamen M, Roßner S. Höfling C, et al. Among authors: kuhn ph. Front Neurosci. 2019 Feb 22;13:137. doi: 10.3389/fnins.2019.00137. eCollection 2019. Front Neurosci. 2019. PMID: 30853883 Free PMC article.

8

Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase.

Kuhn PH, Marjaux E, Imhof A, De Strooper B, Haass C, Lichtenthaler SF. Kuhn PH, et al. J Biol Chem. 2007 Apr 20;282(16):11982-95. doi: 10.1074/jbc.M700356200. Epub 2007 Feb 16. J Biol Chem. 2007. PMID: 17307738 Free article.

9

Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1.

Rudan Njavro J, Klotz J, Dislich B, Wanngren J, Shmueli MD, Herber J, Kuhn PH, Kumar R, Koeglsperger T, Conrad M, Wurst W, Feederle R, Vlachos A, Michalakis S, Jedlicka P, Müller SA, Lichtenthaler SF. Rudan Njavro J, et al. Among authors: kuhn ph. FASEB J. 2020 Feb;34(2):2465-2482. doi: 10.1096/fj.201902347R. Epub 2019 Dec 27. FASEB J. 2020. PMID: 31908000 Free article.

10

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons.

Kuhn PH, Koroniak K, Hogl S, Colombo A, Zeitschel U, Willem M, Volbracht C, Schepers U, Imhof A, Hoffmeister A, Haass C, Roßner S, Bräse S, Lichtenthaler SF. Kuhn PH, et al. EMBO J. 2012 Jun 22;31(14):3157-68. doi: 10.1038/emboj.2012.173. EMBO J. 2012. PMID: 22728825 Free PMC article.

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