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Synthetic mRNAs with superior translation and stability properties.
Grudzien-Nogalska E, Kowalska J, Su W, Kuhn AN, Slepenkov SV, Darzynkiewicz E, Sahin U, Jemielity J, Rhoads RE. Grudzien-Nogalska E, et al. Among authors: kuhn an. Methods Mol Biol. 2013;969:55-72. doi: 10.1007/978-1-62703-260-5_4. Methods Mol Biol. 2013. PMID: 23296927 Review.
mRNA as a versatile tool for exogenous protein expression.
Kuhn AN, Beiβert T, Simon P, Vallazza B, Buck J, Davies BP, Tureci O, Sahin U. Kuhn AN, et al. Curr Gene Ther. 2012 Oct;12(5):347-61. doi: 10.2174/156652312802762536. Curr Gene Ther. 2012. PMID: 22827224 Review.
Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes.
Kowalska J, Wypijewska del Nogal A, Darzynkiewicz ZM, Buck J, Nicola C, Kuhn AN, Lukaszewicz M, Zuberek J, Strenkowska M, Ziemniak M, Maciejczyk M, Bojarska E, Rhoads RE, Darzynkiewicz E, Sahin U, Jemielity J. Kowalska J, et al. Among authors: kuhn an. Nucleic Acids Res. 2014;42(16):10245-64. doi: 10.1093/nar/gku757. Epub 2014 Aug 22. Nucleic Acids Res. 2014. PMID: 25150148 Free PMC article.
Monitoring Translation Activity of mRNA-Loaded Nanoparticles in Mice.
Rosigkeit S, Meng M, Grunwitz C, Gomes P, Kreft A, Hayduk N, Heck R, Pickert G, Ziegler K, Abassi Y, Röder J, Kaps L, Vascotto F, Beissert T, Witzel S, Kuhn A, Diken M, Schuppan D, Sahin U, Haas H, Bockamp E. Rosigkeit S, et al. Mol Pharm. 2018 Sep 4;15(9):3909-3919. doi: 10.1021/acs.molpharmaceut.8b00370. Epub 2018 Aug 9. Mol Pharm. 2018. PMID: 30028629
Improving mRNA-Based Therapeutic Gene Delivery by Expression-Augmenting 3' UTRs Identified by Cellular Library Screening.
Orlandini von Niessen AG, Poleganov MA, Rechner C, Plaschke A, Kranz LM, Fesser S, Diken M, Löwer M, Vallazza B, Beissert T, Bukur V, Kuhn AN, Türeci Ö, Sahin U. Orlandini von Niessen AG, et al. Among authors: kuhn an. Mol Ther. 2019 Apr 10;27(4):824-836. doi: 10.1016/j.ymthe.2018.12.011. Epub 2018 Dec 18. Mol Ther. 2019. PMID: 30638957 Free PMC article.
27 results