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The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer.
J Med Chem. 2008 Sep 25;51(18):5522-32. doi: 10.1021/jm800295d.
J Med Chem. 2008.
PMID: 18754654
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