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Mechanical memory stored through epigenetic remodeling reduces cell therapeutic potential.
Scott AK, Casas E, Schneider SE, Swearingen AR, Van Den Elzen CL, Seelbinder B, Barthold JE, Kugel JF, Stern JL, Foster KJ, Emery NC, Brumbaugh J, Neu CP. Scott AK, et al. Among authors: kugel jf. Biophys J. 2023 Apr 18;122(8):1428-1444. doi: 10.1016/j.bpj.2023.03.004. Epub 2023 Mar 4. Biophys J. 2023. PMID: 36871159 Free PMC article.
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.
Kaneko H, Dridi S, Tarallo V, Gelfand BD, Fowler BJ, Cho WG, Kleinman ME, Ponicsan SL, Hauswirth WW, Chiodo VA, Karikó K, Yoo JW, Lee DK, Hadziahmetovic M, Song Y, Misra S, Chaudhuri G, Buaas FW, Braun RE, Hinton DR, Zhang Q, Grossniklaus HE, Provis JM, Madigan MC, Milam AH, Justice NL, Albuquerque RJ, Blandford AD, Bogdanovich S, Hirano Y, Witta J, Fuchs E, Littman DR, Ambati BK, Rudin CM, Chong MM, Provost P, Kugel JF, Goodrich JA, Dunaief JL, Baffi JZ, Ambati J. Kaneko H, et al. Among authors: kugel jf. Nature. 2011 Mar 17;471(7338):325-30. doi: 10.1038/nature09830. Epub 2011 Feb 6. Nature. 2011. PMID: 21297615 Free PMC article.
XPB, a subunit of TFIIH, is a target of the natural product triptolide.
Titov DV, Gilman B, He QL, Bhat S, Low WK, Dang Y, Smeaton M, Demain AL, Miller PS, Kugel JF, Goodrich JA, Liu JO. Titov DV, et al. Among authors: kugel jf. Nat Chem Biol. 2011 Mar;7(3):182-8. doi: 10.1038/nchembio.522. Epub 2011 Jan 30. Nat Chem Biol. 2011. PMID: 21278739 Free PMC article.
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.
Tarallo V, Hirano Y, Gelfand BD, Dridi S, Kerur N, Kim Y, Cho WG, Kaneko H, Fowler BJ, Bogdanovich S, Albuquerque RJ, Hauswirth WW, Chiodo VA, Kugel JF, Goodrich JA, Ponicsan SL, Chaudhuri G, Murphy MP, Dunaief JL, Ambati BK, Ogura Y, Yoo JW, Lee DK, Provost P, Hinton DR, Núñez G, Baffi JZ, Kleinman ME, Ambati J. Tarallo V, et al. Among authors: kugel jf. Cell. 2012 May 11;149(4):847-59. doi: 10.1016/j.cell.2012.03.036. Epub 2012 Apr 26. Cell. 2012. PMID: 22541070 Free PMC article.
ERK1/2 activation is a therapeutic target in age-related macular degeneration.
Dridi S, Hirano Y, Tarallo V, Kim Y, Fowler BJ, Ambati BK, Bogdanovich S, Chiodo VA, Hauswirth WW, Kugel JF, Goodrich JA, Ponicsan SL, Hinton DR, Kleinman ME, Baffi JZ, Gelfand BD, Ambati J. Dridi S, et al. Among authors: kugel jf. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13781-6. doi: 10.1073/pnas.1206494109. Epub 2012 Aug 6. Proc Natl Acad Sci U S A. 2012. PMID: 22869729 Free PMC article.
66 results